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Titolo:
Peripheral adrenergic system and hypertension
Autore:
Veglio, F; di Cella, SM; Schiavone, D; Paglieri, C; Rabbia, F; Mulatero, P; Chiandussi, L;
Indirizzi:
S Vito Hosp, Dept Med, I-10133 Turin, Italy S Vito Hosp Turin Italy I-10133 ito Hosp, Dept Med, I-10133 Turin, Italy S Vito Hosp, Expt Oncol Hypertens Unit, I-10133 Turin, Italy S Vito Hosp Turin Italy I-10133 col Hypertens Unit, I-10133 Turin, Italy
Titolo Testata:
CLINICAL AND EXPERIMENTAL HYPERTENSION
fascicolo: 1-2, volume: 23, anno: 2001,
pagine: 3 - 14
SICI:
1064-1963(200101/02)23:1-2<3:PASAH>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA(1)-ADRENERGIC RECEPTOR SUBTYPES; SMOOTH-MUSCLE CELLS; BETA-ADRENOCEPTOR; BETA(2)-ADRENOCEPTOR DENSITY; ALPHA-ADRENOCEPTORS; RATS; CLASSIFICATION; LYMPHOCYTES;
Keywords:
assessment of sympathetic activity; adrenoceptor subtypes; adrenoceptor function; peripheral adrenoceptors; alpha-adrenoceptors; beta-adrenoceptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Veglio, F Ctr Ipertens Osped S Vito, Strada S Vito 34, I-10133 Turin, Italy Ctr Ipertens Osped S Vito Strada S Vito 34 Turin Italy I-10133
Citazione:
F. Veglio et al., "Peripheral adrenergic system and hypertension", CLIN EXP HY, 23(1-2), 2001, pp. 3-14

Abstract

Hypertension is a condition where adrenergic responsiveness, sympathetic activity and adrenoceptors are somewhat altered. Many techniques are available to assess human sympathetic nervous system activity. They each present limitations and disadvantages. Characterization and subdivision of the alphaand beta -adrenoceptors, according to their localization and answer to different agonists, was facilitated in recent years by the extensive use of pharmacological and molecular biology techniques. Some adrenoceptor studies: were conducted on animal models, human tissues and peripheral blood cells to assess their changes in various forms and stages of hypertension. Our group has pointed out that alpha (1)-adrenergic receptors expressed by human peripheral blood lymphocytes underwent changes of density in essential hypertensives, compared to normotensive control subjects. The importance of these findings could provide an assessment of alpha(1)-peripheral receptors with possible future clinical implications in thepathophysiology and treatment of hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 07:56:25