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Titolo:
Gestational age and occurrence of atopy at age 31 - a prospective birth cohort study in Finland
Autore:
Pekkanen, J; Xu, B; Jarvelin, MR;
Indirizzi:
Natl Publ Hlth Inst, Environm Epidemiol Unit, FIN-70701 Kuopio, Finland Natl Publ Hlth Inst Kuopio Finland FIN-70701 , FIN-70701 Kuopio, Finland Imperial Coll Sch Med, Dept Epidemiol & Publ Hlth, London, England Imperial Coll Sch Med London England emiol & Publ Hlth, London, England Univ Oulu, Dept Publ Hlth & Gen Practice, Oulu, Finland Univ Oulu Oulu Finland lu, Dept Publ Hlth & Gen Practice, Oulu, Finland
Titolo Testata:
CLINICAL AND EXPERIMENTAL ALLERGY
fascicolo: 1, volume: 31, anno: 2001,
pagine: 95 - 102
SICI:
0954-7894(200101)31:1<95:GAAOOA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RISK-FACTORS; RESPIRATORY SYMPTOMS; FAMILY-SIZE; EARLY-CHILDHOOD; SOCIOECONOMIC-STATUS; EASTERN FINLAND; SCHOOL-AGE; HAY-FEVER; ASTHMA; CHILDREN;
Keywords:
atopy; skin prick test; asthma; birth cohort; follow-up; gestational age; birth weight; farming;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Pekkanen, J Natl Publ Hlth Inst, Environm Epidemiol Unit, POB 95, FIN-70701 Kuopio, Finland Natl Publ Hlth Inst POB 95 Kuopio Finland FIN-70701 , Finland
Citazione:
J. Pekkanen et al., "Gestational age and occurrence of atopy at age 31 - a prospective birth cohort study in Finland", CLIN EXP AL, 31(1), 2001, pp. 95-102

Abstract

Background It has been suggested that main risk factors for development ofallergic diseases operate already during pregnancy and in early childhood. Objective To study the association between gestational age, birth weight, parity and parental farming with the risk of atopy and asthma in young adults. Methods In a prospective birth cohort study, 5192 subjects born in Northern Finland in 1966 were followed up at the age of 31. Skin prick tests were done to three of the most common allergens in Finland and to house dust mite. Data on doctor-diagnosed asthma was obtained from questionnaires. Perinatal data had already been collected during pregnancy. Results The risk of atopy increased linearly with increasing length of pregnancy among babies born in the 35th weak of gestation or later. Gestational age equal to, or over 40 weeks compared with less than 36 weeks was associated with an increased risk of atopy (multivariate odds ratio 1.65, 95% CI1.16, 2.34). The association was stronger among farmers' children (P for interaction 0.01). High parity and being a farmer's child (multivariate oddsratio 0.50, 95% CI 0.42-0.60) was associated with decreased risk of atopy. In contrast, no associations were observed for doctor-diagnosed asthma. Conclusions The results underline the importance of pregnancy and very early childhood in the development of atopy, and suggest that timing of the environmental exposure is of importance for the immune system. No associationwas observed for asthma, which may be due to the multifactorial origins ofasthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 02:57:24