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Titolo:
Rhesus monkey (Macaca mulatta) mucosal antimicrobial peptides are close homologues of human molecules
Autore:
Bals, R; Lang, C; Weiner, DJ; Vogelmeier, C; Welsch, U; Wilson, JM;
Indirizzi:
Hosp Univ Munich, Med Klin & Poliklin 1, Scherpunkt Pneumol, D-81377 Munich, Germany Hosp Univ Munich Munich Germany D-81377 Pneumol, D-81377 Munich, Germany Childrens Hosp Philadelphia, Div Pulm Med, Philadelphia, PA 19104 USA Childrens Hosp Philadelphia Philadelphia PA USA 19104 lphia, PA 19104 USA Wistar Inst, Philadelphia, PA 19104 USA Wistar Inst Philadelphia PA USA 19104 ar Inst, Philadelphia, PA 19104 USA Univ Penn, Dept Med & Mol & Cellular Engn, Inst Human Gene Therapy, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 e Therapy, Philadelphia, PA 19104 USA Univ Munich, Anat Anstalt, D-8000 Munich, Germany Univ Munich Munich Germany D-8000 , Anat Anstalt, D-8000 Munich, Germany
Titolo Testata:
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
fascicolo: 2, volume: 8, anno: 2001,
pagine: 370 - 375
SICI:
1071-412X(200103)8:2<370:RM(MMA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BETA-DEFENSIN-1; MOUSE BETA-DEFENSIN-1; ALPHA-DEFENSINS; AIRWAY SURFACE; BETA-DEFENSIN; HUMAN LUNG; EPITHELIA; LEUKOCYTES; PROTEIN; DEFB2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Bals, R Hosp Univ Munich, Med Klin & Poliklin 1, Scherpunkt Pneumol, Campus Grosshadern,Marchioninistr 15, D-81377 Munich, Germany Hosp Univ Munich Campus Grosshadern,Marchioninistr 15 Munich Germany D-81377
Citazione:
R. Bals et al., "Rhesus monkey (Macaca mulatta) mucosal antimicrobial peptides are close homologues of human molecules", CL DIAG LAB, 8(2), 2001, pp. 370-375

Abstract

One component of host defense at mucosal surfaces appears to be epitheliumderived antimicrobial peptides. Molecules of the defensin and cathelicidinfamilies have been studied in several species, including human and mouse. We describe in this report the identification and characterization of rhesus monkey homologues of human mucosal antimicrobial peptides. Using reverse transcriptase PCR methodology, we cloned the cDNAs of rhesus monkey beta -defensin 1 and 2 (rhBD-1 and rhBD-2) and rhesus monkey LL-37/CAP-18 (rhLL-37/ rhCAP-18). The predicted amino acid sequences showed a high degree of homology to the human molecules. The expression of the monkey antimicrobial peptides was analyzed using immunohistochemistry with three polyclonal antibodies to the human molecules. As in humans, rhesus monkey antimicrobial peptides are expressed in epithelia of various organs, The present study demonstrates that beta- defensins and cathelicidins of rhesus monkeys are close homologues to the human molecules and indicate that nonhuman primates represent valid model organisms to study innate immune functions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 10:24:58