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Titolo:
Lyme borreliosis in rhesus macaques: Effects of corticosteroids on spirochetal load and isotype switching of anti-Borrelia burgdorferi antibody
Autore:
Pachner, AR; Amemiya, K; Bartlett, M; Schaefer, H; Reddy, K; Zhang, WF;
Indirizzi:
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Neurosci, Newark, NJ 07103 USA Univ Med & Dent New Jersey Newark NJ USA 07103 osci, Newark, NJ 07103 USA Georgetown Univ, Sch Med, Dept Neurol, Washington, DC 20057 USA GeorgetownUniv Washington DC USA 20057 Neurol, Washington, DC 20057 USA
Titolo Testata:
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
fascicolo: 2, volume: 8, anno: 2001,
pagine: 225 - 232
SICI:
1071-412X(200103)8:2<225:LBIRME>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE-CHAIN-REACTION; MONONUCLEAR-CELLS; NONHUMAN-PRIMATES; LIPOPROTEIN OSPA; DISEASE; MICE; NEUROBORRELIOSIS; ARTHRITIS; INFECTION; VACCINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Pachner, AR Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Neurosci,185 S Orange St, Newark, NJ 07103 USA Univ Med & Dent New Jersey 185 S Orange St Newark NJ USA 07103
Citazione:
A.R. Pachner et al., "Lyme borreliosis in rhesus macaques: Effects of corticosteroids on spirochetal load and isotype switching of anti-Borrelia burgdorferi antibody", CL DIAG LAB, 8(2), 2001, pp. 225-232

Abstract

Experimental Borrelia burgdorferi infection of rhesus monkeys is an excellent model of Lyme disease and closely parallels the infection in humans. Little is known about the interaction of host immunity with the spirochete inpatients,vith chronic infection. We hypothesized that rapid development ofanti-B. burgdorferi antibody in immunocompetent nonhuman primates (NHPs) is the major determinant of the reduction of the spirochetal load in Lyme borreliosis. This hypothesis was tested by measurement of the spirochetal load by PCR in association with characterization of the anti-B. burgdorferi humoral immune response in immunocompetent NHPs versus that in corticosteroid-treated NHPs, Although anti-B. burgdorferi immunoglobulin G (IgG) antibodywas effectively inhibited in dexamethasone (Dex)-treated NHPs, anti-B, burgdorferi IgM antibody levels continued to rise after the first month and reached levels in excess of IgM levels in immunocompetent NHPs, This vigorousproduction of anti-B. burgdorferi IgM antibodies was also studied in vitroby measurement of antibody produced by B, burgdorferi-stimulated peripheral blood mononuclear cells. Despite these high IgM antispirochetal antibodies in Dex-treated NHPs, spirochetal loads were much higher in these animals. These data indicate that Dex treatment results in interference with isotype switching in this model and provide evidence that anti-B. burgdorferi IgGantibody is much more effective than IgM antibody in decreasing the spirochetal load in infected animals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:23:05