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Titolo:
Suppression of endotoxin- and staphylococcal exotoxin-induced cytokines and chemokines by a phospholipase C inhibitor in human peripheral blood mononuclear cells
Autore:
Krakauer, T;
Indirizzi:
USA, Med Res Inst Infect Dis, Dept Immunol & Mol Biol, Ft Detrick, MD 21702 USA USA Ft Detrick MD USA 21702 Immunol & Mol Biol, Ft Detrick, MD 21702 USA
Titolo Testata:
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
fascicolo: 2, volume: 8, anno: 2001,
pagine: 449 - 453
SICI:
1071-412X(200103)8:2<449:SOEASE>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CLASS-II MOLECULES; SEPTIC SHOCK; FUSION PROTEIN; ENTEROTOXIN-B; RECEPTOR; SUPERANTIGENS; INTERLEUKIN-1; ACTIVATION; MECHANISMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Krakauer, T USA, Med Res Inst Infect Dis, Dept Immunol & Mol Biol, 1425 Porter St, Ft Detrick, MD 21702 USA USA 1425 Porter St Ft Detrick MD USA 21702 trick, MD 21702 USA
Citazione:
T. Krakauer, "Suppression of endotoxin- and staphylococcal exotoxin-induced cytokines and chemokines by a phospholipase C inhibitor in human peripheral blood mononuclear cells", CL DIAG LAB, 8(2), 2001, pp. 449-453

Abstract

Excessive release of proinflammatory cytokines from cells stimulated with lipopolysaccharide (LPS) or staphylococcal exotoxin (SE) mediates the pathophysiologic manifestations of septic shock. Tricyclodecan-9-yl (D609), an inhibitor of phosphatidylcholine-specific phospholipase C, suppressed LPS- or SE-induced cytokines and chemokines in human;peripheral blood mononuclearcells. These data suggest a potential role for D609 in the treatment of septic shock.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 16:07:33