Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IMMUNOLIPOSOMES AS TARGETED DELIVERY VEHICLES FOR CANCER THERAPEUTICS(REVIEW)
Autore:
MACLEAN AL; SYMONDS G; WARD R;
Indirizzi:
ST VINCENTS HOSP,DEPT MED ONCOL,VICTORIA ST DARLINGHURST NSW 2010 AUSTRALIA ST VINCENTS HOSP,DEPT MED ONCOL DARLINGHURST NSW 2010 AUSTRALIA ST VINCENTS HOSP,DEPT CLIN PHARMACOL & TOXICOL DARLINGHURST NSW 2010 AUSTRALIA JOHNSON & JOHNSON RES INST SYDNEY NSW 2010 AUSTRALIA
Titolo Testata:
International journal of oncology
fascicolo: 2, volume: 11, anno: 1997,
pagine: 325 - 332
SICI:
1019-6439(1997)11:2<325:IATDVF>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
STERICALLY STABILIZED LIPOSOMES; PH-SENSITIVE IMMUNOLIPOSOMES; HUMAN GENE-THERAPY; CIRCULATION TIME; IN-VIVO; PLASMID DNA; CATIONIC LIPOSOMES; MESSENGER-RNA; LUNG-CANCER; CELLS;
Keywords:
TARGETED DELIVERY; IMMUNOLIPOSOMES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
95
Recensione:
Indirizzi per estratti:
Citazione:
A.L. Maclean et al., "IMMUNOLIPOSOMES AS TARGETED DELIVERY VEHICLES FOR CANCER THERAPEUTICS(REVIEW)", International journal of oncology, 11(2), 1997, pp. 325-332

Abstract

Advances in liposome technology over the last decade has seen the development of stealth liposomes for drug delivery and cationic liposomesfor gene delivery. Many of these liposome formulations are now in clinical trials for the treatment of a variety of malignancies. Whilst some clinical efficacy has been demonstrated, the goal of specific tumortargeting is yet to be attained. For this reason, antibodies have been attached to the surface of liposomes to produce immunoliposomes. These liposomes have shown preferential binding to specific tumor cells in animal models. The construction of the immunoliposome, and in particular the optimal method of antibody coupling to its surface is, however, yet to be determined. Despite these difficulties, immunoliposomes have demonstrated anti-tumor properties, both in vitro and in vivo, andshow great promise as targeted delivery vehicles for the treatment ofcancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 14:45:50