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Titolo:
Cytokine-induced sickness behavior: Where do we stand?
Autore:
Dantzer, R;
Indirizzi:
INRA, INSERM, U394, F-33077 Bordeaux, France INRA Bordeaux France F-33077 NRA, INSERM, U394, F-33077 Bordeaux, France
Titolo Testata:
BRAIN BEHAVIOR AND IMMUNITY
fascicolo: 1, volume: 15, anno: 2001,
pagine: 7 - 24
SICI:
0889-1591(200103)15:1<7:CSBWDW>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPOPOLYSACCHARIDE-INDUCED EXPRESSION; INTERLEUKIN-1 RECEPTOR ANTAGONIST; BODY-TEMPERATURE; FOS EXPRESSION; RAT-BRAIN; INDUCED ANOREXIA; MESSENGER-RNA; DEPRESSION; MICE; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Dantzer, R INRA, INSERM, U394, F-33077 Bordeaux, France INRA Bordeaux France F-33077 , U394, F-33077 Bordeaux, France
Citazione:
R. Dantzer, "Cytokine-induced sickness behavior: Where do we stand?", BRAIN BEH, 15(1), 2001, pp. 7-24

Abstract

Sickness behavior refers to the coordinated set of behavioral changes thatdevelop in sick individuals during the course of an infection. At the molecular level, these changes are due to the effects of proinflammatory cytokines, such as interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF alpha), in the brain. Peripherally released cytokines act on the brain via a fast transmission pathway involving primary afferent nerves innervating the body site of inflammation and a slow transmission pathway involving cytokines originating from the choroid plexus and circumventricular organs and diffusing into the brain parenchyma by volume transmission. At the behavioral level, sickness behavior appears to be the expression of a central motivational state that reorganizes the organism's priorities to cope with infectious pathogens. There is clinical and experimental evidence that activation ofthe brain cytokine system is associated with depression, although the exact relationship between sickness behavior and depression is still elusive. (C) 2001 Academic Press.

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Documento generato il 09/04/20 alle ore 07:45:39