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Titolo:
Abnormalities of sensorimotor integration in focal dystonia - A transcranial magnetic stimulation study
Autore:
Abbruzzese, G; Marchese, R; Buccolieri, A; Gasparetto, B; Trompetto, C;
Indirizzi:
Univ Genoa, Dipartimento Sci Neurol & Vis, I-16132 Genoa, Italy Univ Genoa Genoa Italy I-16132 to Sci Neurol & Vis, I-16132 Genoa, Italy CNR, Ctr Cerebral Neurophysiol, Genoa, Italy CNR Genoa ItalyCNR, Ctr Cerebral Neurophysiol, Genoa, Italy
Titolo Testata:
BRAIN
, volume: 124, anno: 2001,
parte:, 3
pagine: 537 - 545
SICI:
0006-8950(200103)124:<537:AOSIIF>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOMATOSENSORY-EVOKED-POTENTIALS; PERIPHERAL-NERVE STIMULATION; MUSCLE AFFERENT BLOCK; WRITERS CRAMP; RECIPROCAL INHIBITION; MOTOR CORTEX; INTRACORTICAL INHIBITION; NONINVASIVE EVALUATION; SPASMODIC TORTICOLLIS; CORTICAL INHIBITION;
Keywords:
cortical excitability; focal dystonia; peripheral stimulation; sensorimotor integration; transcranial magnetic stimulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Abbruzzese, G Univ Genoa, Dipartimento Sci Neurol & Vis, Via Toni 5, I-16132 Genoa, Italy Univ Genoa Via Toni 5 Genoa Italy I-16132 6132 Genoa, Italy
Citazione:
G. Abbruzzese et al., "Abnormalities of sensorimotor integration in focal dystonia - A transcranial magnetic stimulation study", BRAIN, 124, 2001, pp. 537-545

Abstract

It has been postulated that sensorimotor integration is abnormal in dystonia, We investigated changes in motor cortical excitability induced by peripheral stimulation in patients with focal hand dystonia (12 patients with hand cramps) and with cervical dystonia (nine with spasmodic torticollis) compared with 16 age-matched normal controls, Motor evoked potentials (MEP) tofocal (figure-of-eight coil) transcranial magnetic stimulation of the handarea were recorded from the right abductor pollicis brevis (APB), first dorsal interosseus (FDI), flexor carpi radialis and extensor carpi radialis muscles. Changes of test MEP size following conditioning stimulation of the right median nerve (or of the index finger) at conditioning-test (C-T) intervals of 50, 200, 600 and 1000 ms were analysed, Peripheral stimulation significantly reduced test MEP size in the APE and FDI muscles of normal control and spasmodic torticollis patients, The inhibitory effect was larger upon median nerve stimulation and reached a maximum at the C-T interval of 200ms, On the contrary, hand cramp patients showed a significant facilitationof test MEP size. This study suggests that MEP suppression following peripheral stimulation is defective in patients with focal hand dystonia, Central processing of sensory input is abnormal in dystonia and may contribute toincreased motor cortical excitability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 10:09:33