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Titolo:
Impact of donor type on outcome of bone marrow transplantation for Wiskott-Aldrich syndrome: collaborative study of the International Bone Marrow Transplant registry and the National Marrow Donor Program
Autore:
Filipovich, AH; Stone, JV; Tomany, SC; Ireland, M; Kollman, C; Pelz, CJ; Casper, JT; Cowan, MJ; Edwards, JR; Fasth, A; Gale, RP; Junker, A; Kamani, NR; Loechelt, BJ; Pietryga, DW; Ringden, O; Vowels, M; Hegland, J; Williams, AV; Klein, JP; Sobocinski, KA; Rowlings, PA; Horowitz, MM;
Indirizzi:
Med Coll Wisconsin, Hlth Policy Inst, Int Bone Marrow Transplant Registry,Ctr Stat, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 r Stat, Milwaukee, WI 53226 USA Natl Marrow Donor Program, Coordinating Ctr, Minneapolis, MN USA Natl Marrow Donor Program Minneapolis MN USA ng Ctr, Minneapolis, MN USA Childrens Hosp, Med Ctr, Div Hematol Oncol, Cincinnati, OH 45229 USA Childrens Hosp Cincinnati OH USA 45229 ol Oncol, Cincinnati, OH 45229 USA Med Coll Wisconsin, Div Pediat Hematol Oncol, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 Oncol, Milwaukee, WI 53226 USA DeVos Childrens Hosp, Grand Rapids, MI USA DeVos Childrens Hosp Grand Rapids MI USA rens Hosp, Grand Rapids, MI USA Univ Calif San Francisco, Pediat Bone Marrow Transplant Program, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Walt Disney Mem Canc Inst, Bone Marrow Transplant Ctr, Orlando, FL USA Walt Disney Mem Canc Inst Orlando FL USA Transplant Ctr, Orlando, FL USA Univ Gothenburg, Dept Pediat, Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden burg, Dept Pediat, Gothenburg, Sweden British Columbia Childrens Hosp, Div Infect Dis & Immunol, Vancouver, BC V6H 3V4, Canada British Columbia Childrens Hosp Vancouver BC Canada V6H 3V4H 3V4, Canada Univ Texas, Hlth Sci Ctr, San Antonio, TX USA Univ Texas San Antonio TX USA v Texas, Hlth Sci Ctr, San Antonio, TX USA Childrens Natl Med Ctr, Washington, DC 20010 USA Childrens Natl Med Ctr Washington DC USA 20010 , Washington, DC 20010 USA Huddinge Univ Hosp, Karolinska Inst, Div Clin Immunol, S-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden S-14186 nol, S-14186 Huddinge, Sweden Sydney Childrens Hosp, Dept Haematol & Oncol, Randwick, NSW, Australia Sydney Childrens Hosp Randwick NSW Australia l, Randwick, NSW, Australia
Titolo Testata:
BLOOD
fascicolo: 6, volume: 97, anno: 2001,
pagine: 1598 - 1603
SICI:
0006-4971(20010315)97:6<1598:IODTOO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TERM FOLLOW-UP; WASP GENE; PATIENT; IMMUNODEFICIENCIES; MUTATIONS; ANEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Horowitz, MM Med Coll Wisconsin, Hlth Policy Inst, Int Bone Marrow Transplant Registry,Ctr Stat, 8701 Watertown Plank Rd,POB 26509, Milwaukee, WI 53226 USA Med Coll Wisconsin 8701 Watertown Plank Rd,POB 26509 Milwaukee WI USA 53226
Citazione:
A.H. Filipovich et al., "Impact of donor type on outcome of bone marrow transplantation for Wiskott-Aldrich syndrome: collaborative study of the International Bone Marrow Transplant registry and the National Marrow Donor Program", BLOOD, 97(6), 2001, pp. 1598-1603

Abstract

Human leukocyte antigen (HLA)-identical sibling bone marrow transplantation is an effective treatment for Wiskott-Aldrich syndrome. However, most children with this disease lack such donors and many patients receive transplants from alternative donors. This study compared outcomes of HLA-identical sibling, other related donor, and unrelated donor transplantation for Wiskott-Aldrich syndrome. The outcome of 170 transplantations for Wiskott-Aldrich syndrome, from 1968 to 1996, reported to the International Bone Marrow Transplant Registry and/or National Marrow Donor Program were assessed. Fifty-five were from HLA-identical sibling donors, 48 from other relatives, and 67 from unrelated donors. Multivariate proportional hazards regression was used to compare outcome by donor type and identify other prognostic factors. Most transplant recipients were younger than 5 years (79%), had a pretransplantation performance score greater than or equal to 90% (63%), received pretransplantation preparative regimens without radiation (82%), and had non-T-cell-depleted grafts (77%), Eighty percent received their transplant after 1986, The 5-year probability of survival (95% confidence interval) for all subjects was 70% (63%-77%), Probabilities differed by donor type: 87% (74%-93%) with HLA-identical sibling donors, 52% (37%-65%) with other related donors, and 71% (58%-80%) with unrelated donors (P = .0006). Multivariateanalysis indicated significantly lower survival using related donors otherthan HLA-identical siblings (P = .0004) or unrelated donors in boys older than 5 years (P = .0001), compared to HLA-identical sibling transplants. Boys receiving an unrelated donor transplant before age 5 had survivals similar to those receiving HLA-identical sibling transplants. The best transplantation outcomes in Wiskott-Aldrich syndrome are achieved with HLA-identicalsibling donors. Equivalent survivals are possible with unrelated donors inyoung children. (Blood. 2001;97:1598-1603) (C) 2001 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 21:12:24