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Titolo:
Peptide methionine sulfoxide reductase: Biochemistry and physiological role
Autore:
Brot, N; Weissbach, H;
Indirizzi:
Cornell Univ, Hosp Special Surg, Weill Med Coll, New York, NY 10021 USA Cornell Univ New York NY USA 10021 Weill Med Coll, New York, NY 10021 USA Florida Atlantic Univ, Ctr Mol Biol & Biotechnol, Boca Raton, FL 33431 USAFlorida Atlantic Univ Boca Raton FL USA 33431 l, Boca Raton, FL 33431 USA
Titolo Testata:
BIOPOLYMERS
fascicolo: 4, volume: 55, anno: 2000,
pagine: 288 - 296
SICI:
0006-3525(2000)55:4<288:PMSRBA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDIZED ALPHA-1-PROTEINASE INHIBITOR; MEMBRANE CA-ATPASE; ESCHERICHIA-COLI; HYDROGEN-PEROXIDE; ENZYMATIC REDUCTION; BIOLOGICAL-ACTIVITY; OXIDATIVE DAMAGE; CIGARETTE-SMOKE; PROTEIN; EXPRESSION;
Keywords:
oxidation; methionine; methionine sulfoxide; methionine sulfoxide reductase; prokaryotic cells; eukaryotic cells; cysteine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Brot, N Cornell Univ, Hosp Special Surg, Weill Med Coll, New York, NY 10021 USA Cornell Univ New York NY USA 10021 d Coll, New York, NY 10021 USA
Citazione:
N. Brot e H. Weissbach, "Peptide methionine sulfoxide reductase: Biochemistry and physiological role", BIOPOLYMERS, 55(4), 2000, pp. 288-296

Abstract

The oxidation of methionine to methionine sulfoxide both in vivo and in vitro can lead to the loss of biological activity in a variety of proteins. This loss of activity can be reversed by an enzyme called methionine sulfoxide reductase. The gene for this enzyme has been cloned and sequenced from avariety of prokaryotic and eukaryotic cells, and the deduced amino acid sequence is very highly conserved. The mechanism of action of the bovine enzyme has been shown to involve a critical cysteine residue located at position 72 of the protein. In addition to its role as a "repair" enzyme, other evidence suggests that the enzyme may be involved in bacterial adherence and regulation of protein activity. (C) 2001 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 17:20:55