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Titolo:
The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding
Autore:
Tanaka, M; Irie, K; Nakagawa, Y; Nakamura, Y; Ohigashi, H; Wender, PA;
Indirizzi:
Kyoto Univ, Grad Sch Agr, Div Appl Life Sci, Sakyo Ku, Kyoto 6068502, Japan Kyoto Univ Kyoto Japan 6068502 Life Sci, Sakyo Ku, Kyoto 6068502, Japan Nagoya Univ, Grad Sch Bioagr Sci, Lab Food & Biodynam, Nagoya, Aichi 4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 ynam, Nagoya, Aichi 4648601, Japan Stanford Univ, Dept Chem, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 iv, Dept Chem, Stanford, CA 94305 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 5, volume: 11, anno: 2001,
pagine: 719 - 722
SICI:
0960-894X(20010312)11:5<719:TCHGOP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYSTEINE-RICH DOMAIN; EPSTEIN-BARR VIRUS; GENERATION; RESPONSES; ISOZYMES; ASSAY; CELLS; SKIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Irie, K Kyoto Univ, Grad Sch Agr, Div Appl Life Sci, Sakyo Ku, Kyoto 6068502, Japan Kyoto Univ Kyoto Japan 6068502 i, Sakyo Ku, Kyoto 6068502, Japan
Citazione:
M. Tanaka et al., "The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding", BIOORG MED, 11(5), 2001, pp. 719-722

Abstract

To investigate the role of the hydroxyl group at position 4 of the phorbolesters in protein kinase C (PKC) binding and function, 4 beta -deoxy-phorbol-12,13-dibutyrate (4 beta -deoxy-PDBu, 5a) and 4 beta -deoxy-phorbol-13-acetate (6a) were synthesized from phorbol (1). The binding affinities of these 4 beta -deoxy compounds (5a, 6a) to the 13 PKC isozyme C1 domains were quite similar to those of the corresponding 4 beta -hydroxy compounds (4a, 4b), suggesting that the C4 hydroxyl group of phorbol esters is not necessary for PKC binding. Moreover, functional assays showed that 4 beta -deoxy-PDBu (5a) exhibited biological activities (Epstein-Barr virus induction and superoxide generation) equally potent to those of PDBu (4a). These solutionphase results differ from expectations based on the previously reported solid-phase structure of the complex of PKC delta -C1B and phorbol-13-acetate(4b). (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:34:15