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Titolo:
Importance of the C28-C38 hydrophobic domain of okadaic acid for potent inhibition of protein serine-threonine phosphatases 1 and 2A
Autore:
Frydrychowski, VA; Urbanek, RA; Dounay, AB; Forsyth, CJ;
Indirizzi:
Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 t Chem, Minneapolis, MN 55455 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 5, volume: 11, anno: 2001,
pagine: 647 - 649
SICI:
0960-894X(20010312)11:5<647:IOTCHD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL PRODUCT INHIBITORS; CALYCULIN-A; 3-DIMENSIONAL STRUCTURE; BINDING; AFFINITY; DERIVATIVES; TAUTOMYCIN; POLYETHER; SUBUNIT; PROTON;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Forsyth, CJ Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 eapolis, MN 55455 USA
Citazione:
V.A. Frydrychowski et al., "Importance of the C28-C38 hydrophobic domain of okadaic acid for potent inhibition of protein serine-threonine phosphatases 1 and 2A", BIOORG MED, 11(5), 2001, pp. 647-649

Abstract

Okadaic acid is a potent inhibitor of select serine/threonine protein phosphatases. The importance of the C28-C38 hydrophobic domain of okadaic acid for inhibition of PP1 and PP2A was investigated. The hydrophobic domain is required but not sufficient for potent inhibition, and it also contributes to differential inhibition between PP1 and PP2A. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 00:07:58