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Titolo:
Stimulation of reactive oxygen species production by an antidepressant visible light source
Autore:
Oren, DA; Charney, DS; Lavie, R; Sinyakov, M; Lubart, R;
Indirizzi:
DVA Connecticut Healthcare Syst, Dept Psychiat, W Haven, CT 06516 USA DVA Connecticut Healthcare Syst W Haven CT USA 06516 Haven, CT 06516 USA Bar Ilan Univ, Dept Phys Chem & Life Sci, Ramat Gan, Israel Bar Ilan UnivRamat Gan Israel Phys Chem & Life Sci, Ramat Gan, Israel
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 5, volume: 49, anno: 2001,
pagine: 464 - 467
SICI:
0006-3223(20010301)49:5<464:SOROSP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEASONAL AFFECTIVE-DISORDER; REDOX REGULATION; CELL-CULTURES; HUMANS; PHOTOTRANSDUCTION; SPERMATOZOA; IRRADIATION; CLOCK;
Keywords:
light; winter; depression; reactive oxygen species; light box; fibroblasts;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Oren, DA DVA Connecticut Healthcare Syst, Dept Psychiat, 950 Campbell Ave,W Haven,CT 06516 USA DVA Connecticut Healthcare Syst 950 Campbell Ave W Haven CT USA 06516
Citazione:
D.A. Oren et al., "Stimulation of reactive oxygen species production by an antidepressant visible light source", BIOL PSYCHI, 49(5), 2001, pp. 464-467

Abstract

Background: The mechanism by which visible light stimulates chronobiological phase-shifting or antidepressant effects in humans is unknown. Methods: Normal human NIH/3T3 nonpigmented fibroblasts were irradiated with a visible light source (SunRay) used in the treatment of winter seasonal depression. Electron spin resonance was assessed before and after 10 min ofillumination at 2 mW/cm(2) (illuminance of 3700 lux), with and without thepresence of 5 muL of 0.0214 mg/mL vitamin C. Results: The fibroblasts showed evidence of production of reactive oxygen species after 10 min of irradiation. Conclusions: These in vitro data establish that an antidepressant source of visible light is capable of inducing the production of reactive oxygen species in skin. Such species may participate in signal transduction pathwaysleading to mood changes. Biol Psychiatry 2001,49:464-467 (C) 2001 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:05:23