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Titolo:
Electroencephalographic and perceptual asymmetry differences between responders and nonresponders to an SSRI antidepressant
Autore:
Bruder, GE; Stewart, JW; Tenke, CE; McGrath, PJ; Leite, P; Bhattacharya, N; Quitkin, FM;
Indirizzi:
New York State Psychiat Inst, Dept Biopsychol, New York, NY 10032 USA New York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA New York State Psychiat Inst, Depress Evaluat Serv, New York, NY 10032 USANew York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 5, volume: 49, anno: 2001,
pagine: 416 - 425
SICI:
0006-3223(20010301)49:5<416:EAPADB>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-DEPRESSED SUBJECTS; MAJOR DEPRESSION; EEG ASYMMETRY; BRAIN; LATERALITY; EMOTION; MOOD; HYPOMETABOLISM; PERFORMANCE; FLUOXETINE;
Keywords:
depression; electroencephalograph; dichotic listening; antidepressant; SSRI; treatment response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Bruder, GE New York State Psychiat Inst, Dept Biopsychol, 1051 Riverside Dr, New York, NY 10032 USA New York State Psychiat Inst 1051 Riverside Dr New York NY USA 10032
Citazione:
G.E. Bruder et al., "Electroencephalographic and perceptual asymmetry differences between responders and nonresponders to an SSRI antidepressant", BIOL PSYCHI, 49(5), 2001, pp. 416-425

Abstract

Background: Recent reports suggest the value of electroencephalographic and dichotic listening measures as predictors of response to antidepressants. This study examines the potential of electroencephalographic alpha asymmetry and dichotic measures of perceptual assymmetry as predictors of clinicalresponse to 12 weeks of treatment with fluoxetine (Prozac),Methods: Resting electroencephalography (eyes open and eyes closed) and dichotic listening with word or complex tone stimuli were assessed in depressed outpatients during a pretreatment period. Results: Fluoxetine responders (n = 34) differed from nonresponders (n = 19) in favoring left over right hemisphere processing of dichotic stimuli. They also differed in their resting electroencephalographic alpha asymmetry,particularly, in the eyes open condition. Nonresponders showed an alpha asymmetry indicative of overall greater activation of the right hemisphere than the left, whereas responders did not. The relationship between hemispheric asymmetry and treatment response interacted with gender, being evident among depressed women but not men. Conclusions: The results are consistent with the hypothesis that a characteristic tendency toward greater left than right hemisphere activation is associated with favorable response to fluoxetine, whereas the opposite hemispheric asymmetry predicts poor response. Biol Psychiatry 2001; 49:416-425 (C) 2001 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:28:05