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Titolo:
Regulation of Pim-1 by Hsp90
Autore:
Mizuno, K; Shirogane, T; Shinohara, A; Iwamatsu, A; Hibi, M; Hirano, T;
Indirizzi:
Osaka Univ, Grad Sch Med, Ctr Biomed Res, Div Mol Oncol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 l Oncol, Suita, Osaka 5650871, Japan Kirin Brewery Co Ltd, Cent Lab Key Technol, Sect Prot Chem, Kanazawa Ku, Kanagawa 2360004, Japan Kirin Brewery Co Ltd Kanagawa Japan 2360004 Ku, Kanagawa 2360004, Japan
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 3, volume: 281, anno: 2001,
pagine: 663 - 669
SICI:
0006-291X(20010302)281:3<663:ROPBH>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAT-SHOCK-PROTEIN; E-MU-MYC; C-MYC; TRANSGENIC MICE; MOLECULAR CHAPERONE; SIGNAL-TRANSDUCTION; KINASE-ACTIVITY; CELLS; PHOSPHORYLATION; IDENTIFICATION;
Keywords:
Pim-1; heat shock protein 90; geldanamycin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Hirano, T Osaka Univ, Grad Sch Med, Ctr Biomed Res, Div Mol Oncol, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 650871, Japan
Citazione:
K. Mizuno et al., "Regulation of Pim-1 by Hsp90", BIOC BIOP R, 281(3), 2001, pp. 663-669

Abstract

The protooncogene Pim-l encodes serine/threonine protein kinases that are involved in cytokine-mediated cell proliferation and in lymphoma- and leukemogenesis. It is largely unknown how Pim-1 executes its biological effects. Here we show that Pim-1 physically interacts with heat shock protein 90 alpha and beta (Hsp90 alpha and beta). The Hsp90-specific inhibitor geldanamycin (GA) induced a rapid degradation of Pim-1 and reduced its kinase activity. The expression of HspS90 alpha was regulated by a signal from the cytokine receptor gp130, as is Pim-1's expression. These results indicate that Hsp90 is coordinately regulated with Pim-1 and is involved in the stabilization and function of Pim-l. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 16:14:53