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Titolo: Regulation of Pim-1 by Hsp90
Autore: Mizuno, K; Shirogane, T; Shinohara, A; Iwamatsu, A; Hibi, M; Hirano, T;
- Indirizzi:
- Osaka Univ, Grad Sch Med, Ctr Biomed Res, Div Mol Oncol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 l Oncol, Suita, Osaka 5650871, Japan Kirin Brewery Co Ltd, Cent Lab Key Technol, Sect Prot Chem, Kanazawa Ku, Kanagawa 2360004, Japan Kirin Brewery Co Ltd Kanagawa Japan 2360004 Ku, Kanagawa 2360004, Japan
- Titolo Testata:
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 3,
volume: 281,
anno: 2001,
pagine: 663 - 669
- SICI:
- 0006-291X(20010302)281:3<663:ROPBH>2.0.ZU;2-2
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- HEAT-SHOCK-PROTEIN; E-MU-MYC; C-MYC; TRANSGENIC MICE; MOLECULAR CHAPERONE; SIGNAL-TRANSDUCTION; KINASE-ACTIVITY; CELLS; PHOSPHORYLATION; IDENTIFICATION;
- Keywords:
- Pim-1; heat shock protein 90; geldanamycin;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Life Sciences
- Citazioni:
- 34
- Recensione:
- Indirizzi per estratti:
- Indirizzo: Hirano, T Osaka Univ, Grad Sch Med, Ctr Biomed Res, Div Mol Oncol, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 650871, Japan
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- Citazione:
- K. Mizuno et al., "Regulation of Pim-1 by Hsp90", BIOC BIOP R, 281(3), 2001, pp. 663-669
Abstract
The protooncogene Pim-l encodes serine/threonine protein kinases that are involved in cytokine-mediated cell proliferation and in lymphoma- and leukemogenesis. It is largely unknown how Pim-1 executes its biological effects. Here we show that Pim-1 physically interacts with heat shock protein 90 alpha and beta (Hsp90 alpha and beta). The Hsp90-specific inhibitor geldanamycin (GA) induced a rapid degradation of Pim-1 and reduced its kinase activity. The expression of HspS90 alpha was regulated by a signal from the cytokine receptor gp130, as is Pim-1's expression. These results indicate that Hsp90 is coordinately regulated with Pim-1 and is involved in the stabilization and function of Pim-l. (C) 2001 Academic Press.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 16:14:53