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Titolo:
Myxothiazol induces H2O2 production from mitochondrial respiratory chain
Autore:
Starkov, AA; Fiskum, G;
Indirizzi:
Univ Maryland, Sch Med, Dept Anesthesiol, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 Anesthesiol, Baltimore, MD 21201 USA
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 3, volume: 281, anno: 2001,
pagine: 645 - 650
SICI:
0006-291X(20010302)281:3<645:MIHPFM>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROGEN-PEROXIDE; HEART-MITOCHONDRIA; ELECTRON-TRANSFER; SUPEROXIDE GENERATION; BC(1) COMPLEX; INHIBITORS; MECHANISM; OXYGEN; OXIDATION; APOPTOSIS;
Keywords:
mitochondria; complex III; reactive oxygen species; hydrogen peroxide; superoxide; myxothiazol; stigmatellin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Fiskum, G Univ Maryland, Sch Med, Dept Anesthesiol, 685 W Baltimore St,MSTF 534, Baltimore, MD 21201 USA Univ Maryland 685 W Baltimore St,MSTF 534 Baltimore MD USA 21201
Citazione:
A.A. Starkov e G. Fiskum, "Myxothiazol induces H2O2 production from mitochondrial respiratory chain", BIOC BIOP R, 281(3), 2001, pp. 645-650

Abstract

Interruption of electron flow at the quinone-reducing center (Q(i)) of complex III of the mitochondrial respiratory chain results in superoxide production. Unstable semiquinone bound in quinol-oxidizing center (Q(o)) of complex In: is thought to be the sole source of electrons for oxygen reduction;however, the unambiguous evidence is lacking We investigated the effects of complex III inhibitors antimycin, myxothiazol, and stigmatellin on generation of H2O2 in rat heart and brain mitochondria. In the absence of antimycin A, myxothiazol stimulated H2O2 production by mitochondria oxidizing malate, succinate, or cr-glycerophosphate. Stigmatellin inhibited H2O2 production induced by myxothiazol. Myxothiazol-induced H2O2 production was dependent on the succinate/fumarate ratio but in a manner different from H2O2 generation induced by antimycin A. We conclude that myxothiazol-induced H2O2 originates from a site located in the complex III Q(o) center but different from the site of H2O2 production inducible by antimycin A (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:07:53