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Titolo:
The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8)
Autore:
Kraan, MC; Patel, DD; Haringman, JJ; Smith, MD; Weedon, H; Ahern, MJ; Breedveld, FC; Tak, PP;
Indirizzi:
Univ Amsterdam, Acad Med Ctr, Dept Med, Div Clin Immunol & Rheumatol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Duke Univ, Med Ctr, Dept Med, Div Rheumatol Allergy & Clin Immunol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 llergy & Clin Immunol, Durham, NC 27710 USA Repatriat Gen Hosp, Daw Pk, SA, Australia Repatriat Gen Hosp Daw Pk SA Australia t Gen Hosp, Daw Pk, SA, Australia Leiden Univ, Med Ctr, Dept Rheumatol, Leiden, Netherlands Leiden Univ Leiden Netherlands Ctr, Dept Rheumatol, Leiden, Netherlands
Titolo Testata:
ARTHRITIS RESEARCH
fascicolo: 1, volume: 3, anno: 2001,
pagine: 65 - 71
SICI:
1465-9913(2001)3:1<65:TDOCSO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; MONOCYTE CHEMOATTRACTANT PROTEIN-1; CRYSTAL-INDUCED ARTHRITIS; TISSUE MACROPHAGES; FACTOR-ALPHA; NEUTROPHIL RECRUITMENT; PERIPHERAL-BLOOD; CELL INFILTRATE; INFLAMED JOINTS; KNEE JOINTS;
Keywords:
arthritis; chemokines; CXCL8; patients; synovium;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Kraan, MC Univ Amsterdam, Acad Med Ctr, Dept Med, Div Clin Immunol & Rheumatol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Meibergdreef 9 Amsterdam Netherlands NL-1105 AZ
Citazione:
M.C. Kraan et al., "The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8)", ARTHRITIS R, 3(1), 2001, pp. 65-71

Abstract

Paired synovial tissue samples were obtained from both clinically uninvolved (CU) and clinically involved (CI) knee joints of eight rheumatoid arthritis (RA) patients. In addition, biopsies were taken from five control subjects. We observed the expression of the chemokines CXCL8, CXCL9, CXCL10, CCL2 and CCL4 in CI and CU joints of RA patients. In particular, CXCL8 proteinlevels were specifically increased in CI joints compared with CU joints, which was confirmed by immunohistochemistry and in situ hybridization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:15:51