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Titolo:
Rheumatoid synovial CD4(+) T cells exhibit a reduced capacity to differentiate into IL-4-producing T-helper-2 effector cells
Autore:
Davis, LS; Cush, JJ; Schulze-Koops, H; Lipsky, PE;
Indirizzi:
Univ Texas, SW Med Ctr, Dept Internal Med, Harold C Simmons Arthrit Res Ctr, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 mons Arthrit Res Ctr, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Dept Internal Med, Div Rheumat Dis, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 Med, Div Rheumat Dis, Dallas, TX 75390 USA Presbyterian Hosp, Dallas, TX USA Presbyterian Hosp Dallas TX USAPresbyterian Hosp, Dallas, TX USA
Titolo Testata:
ARTHRITIS RESEARCH
fascicolo: 1, volume: 3, anno: 2001,
pagine: 54 - 64
SICI:
1465-9913(2001)3:1<54:RSCTCE>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-BLOOD; ARTHRITIS; MEMORY; LYMPHOCYTES; EXPRESSION; TH1; STIMULATION; ACTIVATION; PROTEIN; PEPTIDE;
Keywords:
CD4(+) T-helper cells; cytokines; rheumatoid arthritis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Davis, LS Univ Texas, SW Med Ctr, Dept Internal Med, Harold C Simmons Arthrit Res Ctr, 5323 Harry Hines Blvd, Dallas, TX 75390 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75390 X 75390 USA
Citazione:
L.S. Davis et al., "Rheumatoid synovial CD4(+) T cells exhibit a reduced capacity to differentiate into IL-4-producing T-helper-2 effector cells", ARTHRITIS R, 3(1), 2001, pp. 54-64

Abstract

CD4(+) memory T cells (Tm) from rheumatoid arthritis peripheral blood (RAPB) or peripheral blood from normal donors produced IL-2, whereas fewer cells secreted IFN-gamma or IL-4 after a brief stimulation. RAPB Tm contained significantly more IFN-gamma producers than normal cells. Many rheumatoid arthritis (RA) synovial Tm produced IFN-gamma alone (40%) and fewer cells produced IL-2 or IL-4. An in vitro model was employed to generate polarized T-helper (Th) effecters. Normal and RAPB Tm differentiated into both IFN-gamma- and IL-4-producing effecters. RA synovial fluid (RASF) Tm demonstrated defective responsiveness, exhibiting diminished differentiation of IL-4 effecters, whereas RA synovial tissue (RAST) Tm exhibited defective generation of IFN-gamma and IL-4 producers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:31:44