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Titolo:
Anti-cytokine therapy in chronic destructive arthritis
Autore:
van den Berg, WB;
Indirizzi:
Univ Med Ctr St Radboud, Dept Rheumatol, Rheumatol Res Lab, NL-6500 HB Nijmegen, Netherlands Univ Med Ctr St Radboud Nijmegen Netherlands NL-6500 HB gen, Netherlands
Titolo Testata:
ARTHRITIS RESEARCH
fascicolo: 1, volume: 3, anno: 2001,
pagine: 18 - 26
SICI:
1465-9913(2001)3:1<18:ATICDA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; COLLAGEN-INDUCED ARTHRITIS; INTERLEUKIN-1 RECEPTOR ANTAGONIST; HUMAN SYNOVIAL FIBROBLASTS; FACTOR-ALPHA PRODUCTION; RHEUMATOID-ARTHRITIS; TNF-ALPHA; GENE-TRANSFER; T-CELL; PROINFLAMMATORY CYTOKINES;
Keywords:
animal models; cytokines; inflammation; interleukin-1; joint destruction; tumor necrosis factor;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: van den Berg, WB Univ Med Ctr St Radboud, Dept Rheumatol, Rheumatol Res Lab, NL-6500 HB Nijmegen, Netherlands Univ Med Ctr St Radboud Nijmegen Netherlands NL-6500 HB
Citazione:
W.B. van den Berg, "Anti-cytokine therapy in chronic destructive arthritis", ARTHRITIS R, 3(1), 2001, pp. 18-26

Abstract

Tumor necrosis factor (TNF) and interleukin-1 (IL-1) are considered to be master cytokines in chronic, destructive arthritis. Therapeutic approaches in rheumatoid arthritis (RA) patients have so far focused mainly on TNF, which is a major inflammatory mediator in RA and a potent inducer of IL-1; anti-TNF therapy shows great efficacy in RA patients. However, it is not effective in all patients, nor does it fully control the arthritic process in affected joints of good responders, Directed therapy for IL-1, with IL-1 receptor antagonist, mainly reduces erosions and is marginally anti-inflammatory. It is as yet unclear whether the limited effect is akin to the RA process or linked to suboptimal blocking of IL-1. Analysis of cytokine patterns in early synovial biopsies of RA patients reveals a marked heterogeneity, with variable staining of TNF and IL-1 beta, indicative of TNF-independent IL-1 production in at least some patients. Evidence for this pathway emergedfrom experimental arthritises in rodents, and is summarized in this review. If elements of the models apply to the arthritic process in RA patients, it is necessary to block IL-1 beta in addition to TNF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/02/20 alle ore 14:15:17