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Titolo:
The role of TNF-receptor family members and other TRAF-dependent receptorsin bone resorption
Autore:
Gravallese, EM; Galson, DL; Goldring, SR; Auron, PE;
Indirizzi:
Harvard Univ, Sch Med, Inst Med,Beth Israel Deaconess Med Ctr, New EnglandBaptist Bone & Joint Inst, Boston, MA 02115 USA Harvard Univ Boston MA USA02115 Bone & Joint Inst, Boston, MA 02115 USA
Titolo Testata:
ARTHRITIS RESEARCH
fascicolo: 1, volume: 3, anno: 2001,
pagine: 6 - 12
SICI:
1465-9913(2001)3:1<6:TROTFM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; OSTEOCLAST DIFFERENTIATION FACTOR; NF-KAPPA-B; COLLAGEN-INDUCED ARTHRITIS; INHIBITORY FACTOR; OSTEOPROTEGERIN LIGAND; RHEUMATOID-ARTHRITIS; T-CELLS; C-SRC; TARGETED DISRUPTION;
Keywords:
osteoclasts; RANK; RANKL; TNF-alpha; TRAF;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Gravallese, EM Harvard Univ, Sch Med, Inst Med,Beth Israel Deaconess Med Ctr, New EnglandBaptist Bone & Joint Inst, 4 Blackfan Circle,Room 241, Boston, MA 02115 USA Harvard Univ 4 Blackfan Circle,Room 241 Boston MA USA 02115
Citazione:
E.M. Gravallese et al., "The role of TNF-receptor family members and other TRAF-dependent receptorsin bone resorption", ARTHRITIS R, 3(1), 2001, pp. 6-12

Abstract

The contribution of osteoclasts to the process of bone loss in inflammatory arthritis has recently been demonstrated. Studies in osteoclast biology have led to the identification of factors responsible for the differentiation and activation of osteoclasts, the most important of which is the receptor activator of NF-kappaB ligand/osteoclast differentiation factor (RANKL/ODF), a tumor necrosis factor (TNF)-like protein. The RANKL/ODF receptor, receptor activator of NF-kappaB (RANK), is a TNF-receptor family member present on both osteoclast precursors and mature osteoclasts. Like other TNF-family receptors and the IL-1 receptor, RANK mediates its signal transduction via TNF receptor-associated factor (TRAF) proteins, suggesting that the signaling pathways activated by RANK and other inflammatory cytokines involved in osteoclast differentiation and activation are interconnected.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 23:43:45