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Titolo:
Interplay between bone morphogenetic proteins and cognate binding proteinsin bone and cartilage development: noggin, chordin and DAN
Autore:
Reddi, AH;
Indirizzi:
Univ Calif Davis, Sch Med, Dept Orthopaed Surg, Ctr Tissue Regenerat & Repair, Sacramento, CA 95817 USA Univ Calif Davis Sacramento CA USA 95817 Repair, Sacramento, CA 95817 USA
Titolo Testata:
ARTHRITIS RESEARCH
fascicolo: 1, volume: 3, anno: 2001,
pagine: 1 - 5
SICI:
1465-9913(2001)3:1<1:IBBMPA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
TGF-BETA-SUPERFAMILY; SPEMANN ORGANIZER; XENOPUS EMBRYOS; LIMB; EXPRESSION; FAMILY; MEMBER; CHONDROGENESIS; ANTAGONIST; MUTATION;
Keywords:
BMP; BMP receptors; extracellular matrix; Smads;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Reddi, AH Univ Calif Davis, Sch Med, Dept Orthopaed Surg, Ctr Tissue Regenerat & Repair, 4635 2nd Ave,Bldg 1,Room 2000, Sacramento, CA 95817 USA UnivCalif Davis 4635 2nd Ave,Bldg 1,Room 2000 Sacramento CA USA 95817
Citazione:
A.H. Reddi, "Interplay between bone morphogenetic proteins and cognate binding proteinsin bone and cartilage development: noggin, chordin and DAN", ARTHRITIS R, 3(1), 2001, pp. 1-5

Abstract

This commentary is a concise discussion of the interactions between bone morphogenetic proteins (BMPs) and their binding proteins in bone and cartilage morphogenesis. BMPs are a family of growth and differentiation factors, and they act on mesenchymal cells to induce cartilage and bone differentiation in concentration-dependent thresholds. The BMP-BMP receptor binding leads to a cascade of signaling and transcription of BMP response genes. BMP binding proteins, noggin, chordin and DAN, act as antagonists and determine the bioavailability of BMPs for binding to cognate receptors to elicit the biological response. Noggin null mice with unrestricted action of BMPs exhibit defects in joint morphogenesis. BMPs and their binding proteins may reciprocally regulate the dynamic topography of joints, muscle, tendons and ligaments during morphogenesis of the skeleton. In addition, BMP actions may be potentiated by twisted gastrulation. BMPs and their binding proteins mayplay a critical role in regeneration of cartilage in osteoarthritis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:15:37