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Titolo:
Characterization of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 ORF57 promoter
Autore:
Duan, W; Wang, S; Liu, S; Wood, C;
Indirizzi:
Univ Nebraska, Sch Biol Sci, Lincoln, NE 68588 USA Univ Nebraska Lincoln NE USA 68588 a, Sch Biol Sci, Lincoln, NE 68588 USA Univ Nebraska, Ctr Biol Chem, Lincoln, NE 68588 USA Univ Nebraska LincolnNE USA 68588 , Ctr Biol Chem, Lincoln, NE 68588 USA
Titolo Testata:
ARCHIVES OF VIROLOGY
fascicolo: 2, volume: 146, anno: 2001,
pagine: 403 - 413
SICI:
0304-8608(2001)146:2<403:COKSHH>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; READING FRAME-4 ENCODES; HERPES-SIMPLEX VIRUS; IMMEDIATE-EARLY GENE; TRANSCRIPTIONAL ACTIVATOR; NUCLEOTIDE-SEQUENCE; ORF-57 GENE; SAIMIRI; EXPRESSION; PRODUCT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Wood, C Univ Nebraska, Sch Biol Sci, E249 Beadle Ctr,POB 880666, Lincoln, NE 68588USA Univ Nebraska E249 Beadle Ctr,POB 880666 Lincoln NE USA 68588 8USA
Citazione:
W. Duan et al., "Characterization of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 ORF57 promoter", ARCH VIROL, 146(2), 2001, pp. 403-413

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) is a recently discovered human gamma herpesvirus (HHV-8) that plays an important role in Kaposi's sarcoma development. Here, we further characterize the regulation of the early HHV-8 gene, open reading frame 57 (ORF57). ORF57 is a spliced gene consisting of two exons with a 108-bp intron near the 5' end. The ORF57 mRNA can potentially be initiated at two different start sites, and its expression canbe significantly stimulated by ORF50, an HHV-8 immediate early gene. The target site for ORF50 transactivation was mapped to a 40-bp fragment compassing nt 81904 to 81943 in the ORF57 promoter. Our study on the regulation ofORF57 expression by ORF50 provides the basis for further studies on the regulation of HHV-8 lytic gene expression.

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Documento generato il 16/07/20 alle ore 18:31:29