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Titolo:
The effect of brain atrophy on cerebral hypometabolism in the visual variant of Alzheimer disease
Autore:
Bokde, ALW; Pietrini, P; Ibanez, V; Furey, ML; Alexander, GE; Graff-Radford, NR; Rapoport, SI; Schapiro, MB; Horwitz, B;
Indirizzi:
NIA, Neurosci Lab, NIH, Bethesda, MD 20892 USA NIA Bethesda MD USA 20892NIA, Neurosci Lab, NIH, Bethesda, MD 20892 USA Univ Pisa, Dept Human & Environm Sci, Pisa, Italy Univ Pisa Pisa ItalyUniv Pisa, Dept Human & Environm Sci, Pisa, Italy Belle Idee, Div Neuropsychiat, Geneva, Switzerland Belle Idee Geneva Switzerland e, Div Neuropsychiat, Geneva, Switzerland Arizona State Univ, Arizona Alzheimers Dis Res Ctr, Tempe, AZ USA Arizona State Univ Tempe AZ USA na Alzheimers Dis Res Ctr, Tempe, AZ USA Arizona State Univ, Dept Psychol, Tempe, AZ USA Arizona State Univ Tempe AZ USA State Univ, Dept Psychol, Tempe, AZ USA Mayo Clin, Dept Neurol, Jacksonville, FL 32224 USA Mayo Clin JacksonvilleFL USA 32224 pt Neurol, Jacksonville, FL 32224 USA
Titolo Testata:
ARCHIVES OF NEUROLOGY
fascicolo: 3, volume: 58, anno: 2001,
pagine: 480 - 486
SICI:
0003-9942(200103)58:3<480:TEOBAO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTERIOR CORTICAL ATROPHY; AUTOMATED ALGORITHM; GLUCOSE-UTILIZATION; FUNCTIONAL FAILURE; DEMENTIA; PET; ASSOCIATION; VOLUME; STIMULATION; METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Horwitz, B Natl Inst Deafness & Other Commun Disorders, Language Sect, NIH, Bldg 10,Room 6C420, Bethesda, MD 20892 USA Natl Inst Deafness & Other Commun Disorders Bldg 10,Room 6C420 Bethesda MD USA 20892
Citazione:
A.L.W. Bokde et al., "The effect of brain atrophy on cerebral hypometabolism in the visual variant of Alzheimer disease", ARCH NEUROL, 58(3), 2001, pp. 480-486

Abstract

Background: Brain glucose metabolic rates measured by positron emission tomography can be more affected by partial volume effects in Alzheimer disease (AD) than in healthy aging because of disease-associated brain atrophy. Objective: To determine whether the distinct distribution of cerebral metabolic lesions in patients with the visual variant of AD (AD + VS) represents a true index of neuronal/synaptic dysfunction or is the consequence of brain atrophy. Setting: Government research hospital. Design: Resting cerebral metabolic rate for glucose was measured with positron emission tomography in a cross-sectional study of AD and AD + VS groups and in healthy control subjects. Segmented magnetic resonance im ages were used to correct for brain atrophy. Patients: Patients with AD + VS had prominent visual and visuospatial symptoms. There were 15 patients with AD: 10 with AD + VS, and 37 age-matched control subjects. Main Outcome Measure: Measurement of the rate of cerebral glucose metabolism. Results: Before atrophy correction, the AD + VS group, compared with the control subjects, showed hypometabolism in primary and extrastriate visual areas and in parietal and superior temporal cortical areas. Compared with the AD group, the AD + VS group showed hypometabolism in visual association areas. After atrophy correction, hypometabolism remained significantly different between patients and controls and between the 2 AD groups. Conclusions: The reductions in cerebral hypometabolism represent a true loss of functional activity and are not simply an artifact caused by brain atrophy. The different patterns of hypometabolism indicate the differential development of the lesions between the AD and AD + VS groups.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:08:24