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Titolo:
Association of human herpesvirus 6 infection with drug reaction with eosinophilia and systemic symptoms
Autore:
Descamps, V; Valance, A; Edlinger, C; Fillet, AM; Grossin, M; Lebrun-Vignes, B; Belaich, S; Crickx, B;
Indirizzi:
Hop Bichat Claude Bernard, Dept Dermatol, F-75018 Paris, France Hop BichatClaude Bernard Paris France F-75018 ol, F-75018 Paris, France Hop Bichat Claude Bernard, Dept Anatomopathol, F-75018 Paris, France Hop Bichat Claude Bernard Paris France F-75018 ol, F-75018 Paris, France Hop Bichat Claude Bernard, Dept Virol, F-75018 Paris, France Hop Bichat Claude Bernard Paris France F-75018 ol, F-75018 Paris, France Hop La Pitie Salpetriere, Dept Virol, Assistance Publ Hop, Paris, France Hop La Pitie Salpetriere Paris France ssistance Publ Hop, Paris, France
Titolo Testata:
ARCHIVES OF DERMATOLOGY
fascicolo: 3, volume: 137, anno: 2001,
pagine: 301 - 304
SICI:
0003-987X(200103)137:3<301:AOHH6I>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTICONVULSANT HYPERSENSITIVITY SYNDROME; HUMAN-HERPESVIRUS-6 INFECTION; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Descamps, V Hop Bichat Claude Bernard, Dept Dermatol, 46 Rue Henri Huchard, F-75018 Paris, France Hop Bichat Claude Bernard 46 Rue Henri Huchard Paris France F-75018
Citazione:
V. Descamps et al., "Association of human herpesvirus 6 infection with drug reaction with eosinophilia and systemic symptoms", ARCH DERMAT, 137(3), 2001, pp. 301-304

Abstract

Background: There is a current debate regarding the association of human herpesvirus 6 (HHV-6) infection and drug reaction with eosinophilia and systemic symptoms (DRESS). Methods: Seven consecutive patients hospitalized with DRESS were enrolled in a prospective study to evaluate evidence of active HHV-6 infection. Observations: The imputable drugs were carbamazepine (5 patients), ibuprofen (1 patient), and sulfasalazine (1 patient). All patients were seropositive for anti-HHVd IgG antibodies. Anti-HHV-6 IgM antibodies were detected in4 of the 7 patients with a seroconversion in 2 patients. Neither anti-cytomegalovirus nor anti-Epstein-Barr virus early antigen IgM antibody was detected. Human herpesvirus 6 genome was not detected by polymerase chain reaction in the first serum sample of all patients. It was weakly detected in skin lesions in the last patient tested by polymerase chain reaction but was not found in uninvolved skin. Conclusions: The results suggest an association between HHV-6 active infection (primo-infection or reactivation) and severe DRESS. Absence of anticytomegalovirus or anti-Epstein-Barr virus early antigen IgM antibodies arguesagainst a nonspecific viral reactivation. Human herpesvirus 6 infection may play a role in the development of DRESS in susceptible patients. Some drugs with reactive metabolites could favor reactivation and propagation of HHV-6.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:10:02