Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Targeting superoxide dismutase to renal proximal tubule cells inhibits mitochondrial injury and renal dysfunction induced by cisplatin
Autore:
Nishikawa, M; Nagatomi, H; Chang, BJ; Sato, E; Inoue, M;
Indirizzi:
Osaka City Univ, Sch Med, Dept Biochem, Abeno Ku, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 chem, Abeno Ku, Osaka 5458585, Japan Osaka City Univ, Sch Med, Dept Internal Med, Abeno Ku, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 Med, Abeno Ku, Osaka 5458585, Japan
Titolo Testata:
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
fascicolo: 1, volume: 387, anno: 2001,
pagine: 78 - 84
SICI:
0003-9861(20010301)387:1<78:TSDTRP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXYGEN-FREE RADICALS; INDUCED NEPHROTOXICITY; HYDROGEN-PEROXIDE; RESPIRATORY-CHAIN; CYTOCHROME-C; APOPTOSIS; BCL-2; FAILURE; ALBUMIN; DEATH;
Keywords:
SOD; AH-SOD; cisplatin; reactive oxygen species; kidney; mitochondria; mitochondrial DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Nishikawa, M Osaka City Univ, Sch Med, Dept Biochem, Abeno Ku, 1-4-3 Asahimachi, Osaka 5458585, Japan Osaka City Univ 1-4-3 Asahimachi Osaka Japan 5458585 , Japan
Citazione:
M. Nishikawa et al., "Targeting superoxide dismutase to renal proximal tubule cells inhibits mitochondrial injury and renal dysfunction induced by cisplatin", ARCH BIOCH, 387(1), 2001, pp. 78-84

Abstract

We recently reported the synthesis of a cationic superoxide dismutase (SOD) derivative (AH-SOD) that rapidly and selectively accumulates in and around proximal tubule cells and effectively dismutes superoxide radicals in situ. The present study revealed that administration of cis-diamminedichloroplatinum(II)elicited oxidative stress in renal mitochondria, decreased the renal expression of Bcl-x, released cytochrome c from mitochondria to cytosol, and induced apoptosis and renal dysfunction by a mechanism that was inhibited by AH-SOD, These results suggest that targeting SOD to proximal tubulecells protects renal function and permits the administration of fairly high doses of nephrotoxic anticancer agents, such as cisplatin, without causing renal injury. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 22:52:55