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Titolo:
Surgical resection of non-small cell carcinoma after treatment for small cell carcinoma
Autore:
Smythe, WR; Estrera, AL; Swisher, SG; Merriman, KW; Walsh, GL; Putnam, JB; Vaporciyan, AA; Roth, JA;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Dept Thorac & Cardiovasc Surg, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 & Cardiovasc Surg, Houston, TX 77030 USA
Titolo Testata:
ANNALS OF THORACIC SURGERY
fascicolo: 3, volume: 71, anno: 2001,
pagine: 962 - 966
SICI:
0003-4975(200103)71:3<962:SRONCC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
2ND PRIMARY TUMORS; LUNG-CANCER; SMOKING CESSATION; RADIOTHERAPY; SURVIVORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Smythe, WR Univ Texas, MD Anderson Canc Ctr, Dept Thorac & Cardiovasc Surg, 1515 Holcombe Blvd,Box 109, Houston, TX 77030 USA Univ Texas 1515 Holcombe Blvd,Box 109 Houston TX USA 77030 USA
Citazione:
W.R. Smythe et al., "Surgical resection of non-small cell carcinoma after treatment for small cell carcinoma", ANN THORAC, 71(3), 2001, pp. 962-966

Abstract

Background. Development of non-small cell lung carcinoma (NSCLC) in patients previously treated for small cell carcinoma (SCLC/NSCLC) is well described; however, little is known about clinical outcome. Methods. A single-institution 20-year review was performed. Patient characteristics and survival for SCLC/NSCLC patients were compared with those forcontrol patients matched for stage, resection, and previous malignancy. Results. One thousand four hundred four patients with small cell carcinomawere identified, and 29 underwent therapy for metachronous NSCLC: 11 of 29patients underwent surgical resection, 10 of these 11 (90%) were stage I. Compared with surgically treated stage I NSCLC patients, SCLC/NSCLC patients were more likely to have squamous histology (70% versus 35%, p = 0.026); and subanatomic resection (90% versus 17.4%, p < 0.0005). The SCLC/NSCLC patients had significantly poorer survival when compared with stage I NSCLC patients undergoing any resection (24.53 versus 74.43 months, p 0.003) and stage I NSCLC patients receiving wedge resection (24.53 versus 58.39 months,p = 0.006). Survival was similar to NSCLC patients with a history of previous treated extrathoracic solid malignancy. Conclusions. Surgical resection for SCLC/NSCLC patients is feasible, but poorer prognosis is noted when compared with stage-matched control patients. Surgical candidates should be carefully chosen, and alternative local control modalities considered. (C) 2001 by The Society of Thoracic Surgeons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:15:00