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Titolo:
In situ metabolic and hemodynamic response to dexfenfluramine in white adipose tissue of rats
Autore:
Boschmann, M; Adams, F; Klaus, S;
Indirizzi:
German Inst Human Nutr, Potsdam, Germany German Inst Human Nutr Potsdam Germany nst Human Nutr, Potsdam, Germany
Titolo Testata:
ANNALS OF NUTRITION AND METABOLISM
fascicolo: 1, volume: 45, anno: 2001,
pagine: 24 - 29
SICI:
0250-6807(200101/02)45:1<24:ISMAHR>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
VALVULAR HEART-DISEASE; FENFLURAMINE-PHENTERMINE; HYPOTHALAMIC SEROTONIN; ENERGY-METABOLISM; OBESE PATIENTS; BLOOD-FLOW; WEIGHT; PATTERNS; GLYCEROL; GLUCOSE;
Keywords:
adipose tissue; blood flow; dexfenfluramine; metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Boschmann, M German Inst Human Nutr, Dept Biochem & Physiol Nutr, Arthur Scheunert Allee 114-116, D-14558 Bergholz Rehbrucke, Germany German Inst Human Nutr Arthur Scheunert Allee 114-116 Bergholz Rehbrucke Germany D-14558
Citazione:
M. Boschmann et al., "In situ metabolic and hemodynamic response to dexfenfluramine in white adipose tissue of rats", ANN NUTR M, 45(1), 2001, pp. 24-29

Abstract

Serotonergic neurons are included in the regulation of eating behavior andenergy metabolism. Dexfenfluramine (DF), a serotonin releaser and reuptakeinhibitor, is known to reduce food intake and body weight and to improve the metabolic profile of obese subjects with and without metabolic complications such as type 2 diabetes. Due to cases of valvular heart diseases, DF was withdrawn from the market in 1997. However, serotonergic drugs are stillused in clinical practice. We studied the hemodynamic and metabolic changes induced by in situ perfusion of inguinal subcutaneous adipose tissue (SAT) of normal-weight rats with either 1 muM isoproterenol (IP) or 5 muM DF using the microdialysis technique. Perfusion of SAT with IP resulted in an increase in blood flow (+25%) and lipolysis (+35%) when compared to baseline. In contrast to that, perfusion of SAT with DF resulted in a decrease in blood flow (-25%) and lipolysis (-35%). Additionally, dialysate glucose was decreased and dialysate lactate was increased during perfusion with DF, indicating stimulation of glucose uptake and the glycolytic pathway. It is concluded that DF reduces blood flow and lipolysis whereas it stimulates the glycolytic pathway in SAT and that this could contribute to the positive metabolic outcome, i.e., lowered blood lipids and fat mass of DF-treated obese subjects. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 03:39:11