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Titolo:
Assessing the risks and benefits of benzodiazepines for anxiety disorders in patients with a history of substance abuse or dependence
Autore:
Posternak, MA; Mueller, TI;
Indirizzi:
Brown Univ, Dept Psychiat & Human Behav, Providence, RI 02905 USA Brown Univ Providence RI USA 02905 Human Behav, Providence, RI 02905 USA
Titolo Testata:
AMERICAN JOURNAL ON ADDICTIONS
fascicolo: 1, volume: 10, anno: 2001,
pagine: 48 - 68
SICI:
1055-0496(200124)10:1<48:ATRABO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTTRAUMATIC-STRESS-DISORDER; PSYCHOTROPIC-DRUG USE; TERM THERAPEUTIC USE; NATIONAL-COMORBIDITY-SURVEY; QUALITY-OF-LIFE; PANIC DISORDER; SOCIAL PHOBIA; FOLLOW-UP; GENERALIZED ANXIETY; PSYCHIATRIC-DISORDERS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
197
Recensione:
Indirizzi per estratti:
Indirizzo: Posternak, MA Brown Univ, Dept Psychiat & Human Behav, 235 Plain St,Suite 501, Providence, RI 02905 USA Brown Univ 235 Plain St,Suite 501 Providence RI USA 02905 SA
Citazione:
M.A. Posternak e T.I. Mueller, "Assessing the risks and benefits of benzodiazepines for anxiety disorders in patients with a history of substance abuse or dependence", AM J ADDICT, 10(1), 2001, pp. 48-68

Abstract

In this article, the authors reevaluate the traditional position that benzodiazepines should be avoided in anxiety disorder patients with a history of substance abuse or dependence. The efficacy of benzodiazepines in each ofthe anxiety disorders is reviewed, as are their side effects and toxicity. The definitions of benzodiazepine abuse and dependence are discussed, and relevant animal, experimental, and clinical data are reviewed and analyzed. A manual and computerized (MEDLINE) search was performed from 1996 to the present to examine the English-language literature published on benzodiazepines, substance abuse, and each of the anxiety disorders listed in DSM-IV The authors found that benzodiazepines have demonstrated efficacy in generalized anxiety disorder, panic disorder, and agoraphobia, they are promising agents in the treatment of social phobia and alcohol-induced anxiety disorders. They are generally, well tolerated There is much ambiguity over appropriate definitions Sor benzodiazepine abuse and dependence: although most benzodiazepine abusers concurrently abuse other substances, there is little evidence to indicate that a history of substance abuse is a major risk factor for future benzodiazepine abuse or dependence. Furthermore, benzodiazepines do not appear to induce relapse of substance abuse in these patients. The authors conclude that the Position that benzodiazepines are contraindicated informer substance abusers appears to lack empirical justification. Benzodiazepines may be indicated in certain patients with anxiety disorders anda history of substance abuse or dependence.

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Documento generato il 23/10/20 alle ore 14:18:23