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Titolo:
Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers
Autore:
Volkow, ND; Chang, L; Wang, GJ; Fowler, JS; Leonido-Yee, M; Franceschi, D; Sedler, MJ; Gatley, SJ; Hitzemann, R; Ding, YS; Logan, J; Wong, C; Miller, EN;
Indirizzi:
Brookhaven Natl Lab, Upton, NY 11973 USA Brookhaven Natl Lab Upton NY USA11973 aven Natl Lab, Upton, NY 11973 USA Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 hiat, Stony Brook, NY 11794 USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 3, volume: 158, anno: 2001,
pagine: 377 - 382
SICI:
0002-953X(200103)158:3<377:AODTRW>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; PARKINSONS-DISEASE; INDUCED NEUROTOXICITY; C-11 WIN-35,428; PET LIGAND; BRAIN; BINDING; USERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Volkow, ND Brookhaven Natl Lab, Bldg 490,POB 5000, Upton, NY 11973 USA Brookhaven Natl Lab Bldg 490,POB 5000 Upton NY USA 11973 73 USA
Citazione:
N.D. Volkow et al., "Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers", AM J PSYCHI, 158(3), 2001, pp. 377-382

Abstract

Objective: Methamphetamine is a popular and highly addictive drug of abusethat has raised concerns because it has been shown in laboratory animals to be neurotoxic to dopamine terminals. The authors evaluated if similar changes occur in humans and assessed if they were functionally significant. Method: Positron emission tomography scans following administration of [C-11]d-threo-methyl phenidate (a dopamine transporter ligand) measured dopamine transporter levels (a marker of dopamine cell terminals) in the brains of 15 detoxified methamphetamine abusers and 18 comparison subjects. Neuropsychological tests were also performed to assess motor and cognitive function. Results: Methamphetamine abusers showed significant dopamine transporter reduction in the striatum (mean differences of 27.8% in the caudate and 21.1% in the putamen) relative to the comparison subjects; this reduction was evident even in abusers who had been detoxified for at least 11 months. Dopamine transporter reduction was associated with motor slowing and memory impairment. Conclusions: These results provide evidence that methamphetamine at dose levels taken by human abusers of the drug leads to dopamine transporter reduction that is associated with motor and cognitive impairment. These resultsemphasize the urgency of alerting clinicians and the public of the long-term changes that methamphetamine can induce in the human brain.

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Documento generato il 30/11/20 alle ore 02:15:26