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Titolo:
Lactation decreases angiotensinogen mRNA expression in the midcaudal arcuate nucleus of the rat brain
Autore:
Speth, RC; Smith, MS; Grove, KL;
Indirizzi:
Oregon Hlth Sci Univ, Oregon Reg Primate Res Ctr, Div Neurosci, Beaverton,OR 97006 USA Oregon Hlth Sci Univ Beaverton OR USA 97006 rosci, Beaverton,OR 97006 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 4, volume: 280, anno: 2001,
pagine: R1169 - R1176
SICI:
0363-6119(200104)280:4<R1169:LDAMEI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; CENTRAL-NERVOUS-SYSTEM; NEUROPEPTIDE-Y NPY; GENE-EXPRESSION; DIFFERENTIAL REGULATION; DOPAMINERGIC-NEURONS; LUTEINIZING-HORMONE; CONVERTING-ENZYME; MOLECULAR-BIOLOGY; ADRENAL-STEROIDS;
Keywords:
tuberoinfundibular dopamine neurons; astrocytes; prolactin secretion; hypothalamus; in situ hybridization histochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Speth, RC Washington State Univ, Dept Vet Comp Anat Pharmacol Physiol, POB646520, Pullman, WA 99164 USA Washington State Univ POB 646520 Pullman WA USA 99164 99164 USA
Citazione:
R.C. Speth et al., "Lactation decreases angiotensinogen mRNA expression in the midcaudal arcuate nucleus of the rat brain", AM J P-REG, 280(4), 2001, pp. R1169-R1176

Abstract

In lactating rats, ANG II receptor binding in the arcuate nucleus (ARH) and median eminence is decreased. To further evaluate brain angiotensinergic activity during lactation, we assessed angiotensinogen (AON) mRNA by in situ hybridization in forebrains of day 10 or 11 postpartum lactating and diestrous rats. AON mRNA was abundantly expressed in the ARH, preoptic, suprachiasmatic, supraoptic, paraventricular, and dorsomedial hypothalamic nuclei,and other regions, similar to that reported in male rat brains. AON mRNA levels were decreased 27% in the midcaudal ARH of lactating rats but did notdiffer between lactating or diestrous rats in any of the other brain areasexamined. Immunofluorescence for AON and glial fibrillary acidic protein or tyrosine hydroxylase confirmed that the AON immunoreactivity in the ARH was limited to astrocytes. Confocal microscopy revealed close appositions ofAON-positive astrocytes to dopaminergic neurons in the ARH. The decrease in AON mRNA in the midcaudal ARH during lactation coupled with decreased ARHANG II receptor binding suggests that lactating rats are less subject to ANG II-mediated inhibition of prolactin secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:55:34