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Titolo:
Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans
Autore:
Beglinger, C; Degen, L; Matzinger, D; DAmato, M; Drewe, J;
Indirizzi:
Univ Basel Hosp, Div Gastroenterol, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 ol, CH-4031 Basel, Switzerland Univ Basel Hosp, Dept Res, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 es, CH-4031 Basel, Switzerland Univ Basel Hosp, Div Clin Pharmacol, CH-4031 Basel, Switzerland Univ BaselHosp Basel Switzerland CH-4031 ol, CH-4031 Basel, Switzerland Rotta Res Lab, I-20052 Monza, Italy Rotta Res Lab Monza Italy I-20052Rotta Res Lab, I-20052 Monza, Italy
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 4, volume: 280, anno: 2001,
pagine: R1149 - R1154
SICI:
0363-6119(200104)280:4<R1149:LACRAS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCAGON-LIKE PEPTIDE-1; DECREASES FOOD-INTAKE; PLASMA CHOLECYSTOKININ; BODY-WEIGHT; GALLBLADDER CONTRACTION; PROMOTES SATIETY; EATING BEHAVIOR; RATS; FAT; INHIBITION;
Keywords:
cholecystokinin; appetite; eating behavior;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Beglinger, C Univ Basel Hosp, Div Gastroenterol, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 asel, Switzerland
Citazione:
C. Beglinger et al., "Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans", AM J P-REG, 280(4), 2001, pp. R1149-R1154

Abstract

Exogenous cholecystokinin (CCK) induces early satiety when infused into humans. Whether alimentary CCK (CCK-A) receptor blockade stimulates food intake in humans is, however, uncertain. The aim of the present investigation was, therefore, to establish the effect of CCK-A receptor blockade on satiety and eating behavior in healthy volunteers. To further explore the role ofendogenous CCK, the effects of the specific CCK-A receptor antagonist loxiglumide (Lox; 22 mu mol.kg(-1).h(-1)) on satiety and eating behavior were investigated in healthy men and compared with saline infusions (as placebo) in a series of randomized, double-blind, placebo-controlled, crossover studies. Lox produced a slight (7%), but not significant (P = 0.104), increase in food intake that was accompanied by a modest (10%), but significant (P<0.004), increase in calorie intake. Fluid ingestion was not affected by Lox. Subjects experienced more hunger and delayed fullness during Lox infusion than during saline infusion (P< 0.05). This study provides further evidencethat CCK is an endogenous physiological satiety signal acting through CCK-A receptor-mediated mechanisms. Repeated-dose studies comparing hunger and satiety responses after CCK-A receptor blockade in healthy subjects and patients with eating disorders may help clarify the possible involvement of endogenous CCK in these conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 14:12:20