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Titolo:
Parabrachial nucleus modulates cardiovascular responses to blood loss
Autore:
Blair, ML; Jaworski, RL; Want, A; Piekut, DT;
Indirizzi:
Univ Rochester, Sch Med & Dent, Dept Physiol & Pharmacol, Rochester, NY 14642 USA Univ Rochester Rochester NY USA 14642 Pharmacol, Rochester, NY 14642 USA Univ Rochester, Sch Med & Dent, Dept Neurobiol & Anat, Rochester, NY 14642USA Univ Rochester Rochester NY USA 14642 biol & Anat, Rochester, NY 14642USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 4, volume: 280, anno: 2001,
pagine: R1141 - R1148
SICI:
0363-6119(200104)280:4<R1141:PNMCRT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-FOS EXPRESSION; PARAVENTRICULAR NUCLEUS; MAGNOCELLULAR NEURONS; TRACTUS-SOLITARIUS; HYPERTENSIVE RATS; VASOPRESSIN; STIMULATION; RENIN; CONNECTIONS; HYPOTENSION;
Keywords:
blood pressure; heart rate; renin; corticosterone; supraoptic nucleus; Fos;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Blair, ML Univ Rochester, Sch Med & Dent, Dept Physiol & Pharmacol, Box 711,601 Elmwood Ave, Rochester, NY 14642 USA Univ Rochester Box 711,601 Elmwood Ave Rochester NY USA 14642 SA
Citazione:
M.L. Blair et al., "Parabrachial nucleus modulates cardiovascular responses to blood loss", AM J P-REG, 280(4), 2001, pp. R1141-R1148

Abstract

The goal of this study was to determine the role of the pontine lateral parabrachial nucleus (LPBN) in the compensatory responses to blood loss. Conscious unrestrained rats with complete, partial, or sham bilateral ibotenic acid lesions of the LPBN were subjected to a hypotensive 16-ml/kg blood withdrawal via arterial catheter. Complete lesions (LPBNx) encompassed the entire LPBN and extended into the ventrolateral parabrachial region to encroach on the Kolliker-Fuse nucleus. Partial lesions were restricted to the bodyof the LPBN and spared the outer rim of the external lateral subnucleus ofthe LPBN. In all three groups, serum corticosterone concentration and plasma renin activity increased four- to fivefold after hemorrhage (P< 0.01), and immunocytochemistry demonstrated numerous Fos-positive neurons in the hypothalamic supraoptic nucleus. However, the cardiovascular responses to hypotensive blood loss differed for complete and partial lesions. Blood pressure failed to recover in LPBNx rats and was significantly lower in LPBNx (66+/- 4 mmHg) than in rats with partial or sham lesions (98 +/- 4 and 85 +/-5 mmHg, respectively) at 40 min posthemorrhage. In contrast, rats with partial lesions had a significant attenuation of the posthemorrhage bradycardia. This implies that a population of neurons within the body of the LPBN isessential for full expression of the bradycardia that accompanies hemorrhagic hypotension, whereas the ventrolateral parabrachial region is essentialfor normal restoration of arterial pressure after hypotensive hemorrhage.

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Documento generato il 04/04/20 alle ore 12:14:51