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Titolo:
Effect of repetitive icv injections of ANG II on c-Fos and AT(1)-receptor expression in the rat brain
Autore:
Moellenhoff, E; Blume, A; Culman, J; Chatterjee, B; Herdegen, T; Lebrun, CJ; Unger, T;
Indirizzi:
Univ Kiel, Inst Pharmacol, D-24105 Kiel, Germany Univ Kiel Kiel Germany D-24105 el, Inst Pharmacol, D-24105 Kiel, Germany German Inst High Blood Pressure Res, D-69120 Heidelberg, Germany German Inst High Blood Pressure Res Heidelberg Germany D-69120 , Germany Gesselschaft Strahlenforsch, Natl Res Ctr Environm & Hlth, Inst Mammalian Genet, D-85764 Neuherberg, Germany Gesselschaft Strahlenforsch NeuherbergGermany D-85764 uherberg, Germany
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 4, volume: 280, anno: 2001,
pagine: R1095 - R1104
SICI:
0363-6119(200104)280:4<R1095:EORIIO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
EARLY GENE-EXPRESSION; DIFFERENTIAL TIME-COURSE; LASTING AP-1 COMPLEX; TRANSCRIPTION FACTORS; ELECTROCONVULSIVE SEIZURES; KROX-24 PROTEINS; CHRONIC COCAINE; DOWN-REGULATION; NERVOUS-SYSTEM; ANGIOTENSIN;
Keywords:
chronic stimulation; desensitization; inducible transcription factor; constitutive transcription factor; angiotensin AT(1); receptor; intracerebroventricular;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Unger, T Univ Kiel, Inst Pharmacol, Hosp Str 4, D-24105 Kiel, Germany UnivKiel Hosp Str 4 Kiel Germany D-24105 D-24105 Kiel, Germany
Citazione:
E. Moellenhoff et al., "Effect of repetitive icv injections of ANG II on c-Fos and AT(1)-receptor expression in the rat brain", AM J P-REG, 280(4), 2001, pp. R1095-R1104

Abstract

ANG II has been implicated in neuroplastic processes via stimulation of inducible transcription factors (ITF) in the brain. In the present study, we investigated the effects of acute vs. repetitive once daily intracerebroventricular injections of ANG II for 7 days on the expression of ITF and constitutive transcription factor (CTF) and the AT(1) receptor in the median preoptic area (MnPO), the subfornical organ (SFO), and the hypothalamic paraventricular (PVN) and supraoptic nuclei (SON). After repetitive injections, the expression of c-Fos declined by similar to 50% in MnPO, SFO, PVN, and SON compared with controls injected once. The desensitization of c-Fos occurred on the transcriptional level as shown in the SON by RT-PCR. Apart from anovel expression of c-Jun in the SON, the ITF c-Jun, JunB, JunD, and Krox-24 did not change after repetitive stimulation. Neither were the CTF, calcium response element binding protein, activating transcription factor 2, andserum response factor altered after repetitive vs. single injections of ANG II. The AT(1) receptor was coexpressed with c-Fos/c-Jun. Immunohistochemical stainings suggest an increase in AT(1) receptor number in MnPO, SFO, PVN, and SON on chronic stimulation compared with once-injected controls. These findings demonstrate that repetitive periventricular stimulation with ANG II essentially alters the expression of transcription factors compared with acute stimulation and suggest c-Fos and c-Jun as major intermediates of the AT(1) receptor transcription.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:07:53