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Titolo:
Muscimol infusions in the brain stem reticular formation reversibly block ingestion in the awake rat
Autore:
Chen, ZX; Travers, SP; Travers, JB;
Indirizzi:
Ohio State Univ, Coll Dent, Sect Oral Biol, Columbus, OH 43218 USA Ohio State Univ Columbus OH USA 43218 t Oral Biol, Columbus, OH 43218 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 4, volume: 280, anno: 2001,
pagine: R1085 - R1094
SICI:
0363-6119(200104)280:4<R1085:MIITBS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
RHYTHMICAL JAW MOVEMENTS; HYPOGLOSSAL NEURAL ACTIVITY; TASTE REACTIVITY TEST; MOTOR NUCLEI; SOLITARY TRACT; GUINEA-PIG; MIMETIC RESPONSES; GUSTATORY STIMULI; ROSTRAL NUCLEUS; CONNECTIONS;
Keywords:
central pattern generator; licking; mastication; feeding;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Travers, JB Ohio State Univ, Coll Dent, Sect Oral Biol, POB 182357,305 W &12th Ave, Columbus, OH 43218 USA Ohio State Univ POB 182357,305 W & 12th Ave Columbus OH USA 43218
Citazione:
Z.X. Chen et al., "Muscimol infusions in the brain stem reticular formation reversibly block ingestion in the awake rat", AM J P-REG, 280(4), 2001, pp. R1085-R1094

Abstract

Previous studies have localized a central pattern generator for mastication to the midline pontomedullary reticular formation (RF) based on cortically induced ororhythmic movements. The present study determined whether this same substrate mediated licking responses evoked by more natural stimuli. Licking in the awake rat was initiated either through an appetitive responseto sucrose presented in a bottle or by intraoral (IO) infusions. Oral rejection responses also were obtained by IO infusions of quinine hydrochloride. Small volumes of the GABA(A) agonist muscimol bilaterally infused into the lateral medullary RF significantly reduced licking and oral rejection responses measured electromyographically from the anterior digastric and geniohyoid muscles. Other than the decrement or absence of ororhythmic activity,rats appeared normal and actively approached and probed the water bottle. The suppression was reversible and returned to baseline within 3 h. In contrast, midline infusions of muscimol did not affect licking or rejection responses. We postulate that the lateral medullary RF is an essential final common path for ingestive consummatory responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:03:29