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Titolo:
Nonnoradrenergic mechanism of reflex cutaneous vasoconstriction in men
Autore:
Stephens, DP; Aoki, K; Kosiba, WA; Johnson, JM;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Physiol 7756, San Antonio, TX 78229 USA Univ Texas San Antonio TX USA 78229 ysiol 7756, San Antonio, TX 78229 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 4, volume: 280, anno: 2001,
pagine: H1496 - H1504
SICI:
0363-6135(200104)280:4<H1496:NMORCV>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC VASCULAR CONTROL; LASER-DOPPLER FLOWMETRY; RABBIT EAR ARTERY; NEUROPEPTIDE-Y; BLOOD-FLOW; NERVOUS-SYSTEM; HUMAN FOREARM; RESPONSES; SKIN; COTRANSMISSION;
Keywords:
skin blood flow; sympathetic nervous system; cold stress; yohimbine; propranolol; beta-adrenergic receptors; cotransmitter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Johnson, JM Univ Texas, Hlth Sci Ctr, Dept Physiol 7756, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA Univ Texas 7703 Floyd Curl Dr San Antonio TX USA 78229 229 USA
Citazione:
D.P. Stephens et al., "Nonnoradrenergic mechanism of reflex cutaneous vasoconstriction in men", AM J P-HEAR, 280(4), 2001, pp. H1496-H1504

Abstract

We tested for a nonnoradrenergic mechanism of reflex cutaneous vasoconstriction with whole body progressive cooling in seven men. Forearm sites (<1 cm(2)) were pretreated with: 1) yohimbine (Yoh; 5 mM id) to antagonize <alpha>-adrenergic receptors, 2) Yoh plus propranolol (5 mM Yoh- 1 mM PR id) to block alpha- and beta- adrenergic receptors, 3) iontophoretic application of bretylium tosylate (BT) to block all sympathetic vasoconstrictor nerve effects, or 4) intradermal saline. Skin blood flow was measured by laser Doppler flowmetry and arterial pressure by finger photoplethysmography; cutaneous vascular conductance (CVC) was indexed as the ratio of the two. Whole body skin temperature (T-SK) was controlled at 34 degrees C (water- perfused suit) for 10 min and then lowered to 31 degrees C over 15 min. During cooling, vasoconstriction was blocked at BT sites (P > 0.05). CVC at saline sites fell significantly beginning at TSK of 33.4 +/- 0.01 degrees C (P < 0.05). CVC at Yoh- PR sites was significantly reduced beginning at TSK of 33.0 +/- 0.01<degrees>C (P < 0.05). After cooling, iontophoretic application of norepinephrine (NE) confirmed blockade of adrenergic receptors by Yoh- PR. Because the effects of NE were blocked at sites showing significant reflex vasoconstriction, a nonnoradrenergic mechanism in human skin is indicated, probably via a sympathetic cotransmitter.

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Documento generato il 19/01/20 alle ore 14:33:26