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Titolo:
Involvement of urban living environments in atopy and enhanced eosinophil activity: potential risk factors of airway allergic symptoms
Autore:
Kuwahara, Y; Kondoh, J; Tatara, K; Azuma, E; Nakajima, T; Hashimoto, M; Komachi, Y;
Indirizzi:
Osaka Univ, Sch Med, Dept Social & Environm Med, Osaka, Japan Osaka Univ Osaka Japan ch Med, Dept Social & Environm Med, Osaka, Japan Osaka Prefectural Inst Publ Hlth, Osaka 537, Japan Osaka Prefectural Inst Publ Hlth Osaka Japan 537 Hlth, Osaka 537, Japan
Titolo Testata:
ALLERGY
fascicolo: 3, volume: 56, anno: 2001,
pagine: 224 - 230
SICI:
0105-4538(200103)56:3<224:IOULEI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKIN-TEST REACTIVITY; HOUSE-DUST MITES; HYPERSENSITIVITY PNEUMONITIS; BRONCHIAL HYPERREACTIVITY; RESPIRATORY HEALTH; CIGARETTE SMOKERS; ASTHMA; CHILDREN; PREVALENCE; SENSITIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Kuwahara, Y 69-3,1 Chome,Higashinari Ku, Osaka 5370025, Japan 69-3,1 Chome,Higashinari Ku Osaka Japan 5370025 70025, Japan
Citazione:
Y. Kuwahara et al., "Involvement of urban living environments in atopy and enhanced eosinophil activity: potential risk factors of airway allergic symptoms", ALLERGY, 56(3), 2001, pp. 224-230

Abstract

Background: Airway allergic diseases, such as bronchial asthma and allergic rhinitis, have increased, especially in urban areas. These diseases are characterized by airway inflammation with enhanced eosinophil activity, and the risk of disease development has been shown to increase with the prevalence of atopy. Methods: Questionnaires were administered to 426 healthy adult women aged 30-74 years, living in an urban area of Osaka, Japan, to survey individual living environments and airway allergic symptoms such as cough, sputum, andwheezing. Moreover, serum house-dust-mite (Dermatophagoides pteronyssinus,[Der p])-specific immunoglobulin E (IgE) and serum eosinophil cationic protein (ECP) were examined by radioimmunoassay, and the atopic status (atopicsensitization) and enhanced eosinophil activity were assessed as Der p-specific IgE RAST scores of 2-6 and ECP levels of more than 10 ng/ml, respectively. Results: Intensive use of electric air conditioners in hot weather (odds ratio: 2.07 [95%, CI: 1.11-3.87]) and mold proliferation in the kitchen (2.77 [1.34-5.73]) significantly increased the risk of atopic sensitization. Poor home ventilation and family smoking appeared to be positively but not significantly associated with atopic sensitization. Personal smoking and intensive use of the air conditioner appeared to be positively related to enhanced eosinophil activity. Atopic status showed significant involvement in the development of wheezing, and the development of cough was significantly associated with enhanced eosinophil activity. Conclusions: The results suggest that some urban styles of living are involved in atopic sensitization and enhanced eosinophil activity in the Japanese urban population, probably due to living conditions, such as indoor dampness and poor home ventilation, caused by tight insulation, which increase exposure to indoor air pollutants, such as respirable mite allergens and tobacco smoke.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/18 alle ore 08:13:37