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Titolo:
Discontinuation of primary prophylaxis in HIV-infected patients at high risk of Pneumocystis carinii pneumonia: prospective multicentre study
Autore:
Furrer, H; Opravil, M; Rossi, M; Bernasconi, E; Telenti, A; Bucher, H; Schiffer, V; Boggian, K; Rickenbach, M; Flepp, M; Egger, M;
Indirizzi:
Univ Zurich, Div Infect Dis, CH-8006 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8006 Dis, CH-8006 Zurich, Switzerland Univ Bern, Div Infect Dis, CH-3012 Bern, Switzerland Univ Bern Bern Switzerland CH-3012 Infect Dis, CH-3012 Bern, Switzerland Univ Lausanne, Div Hosp Prevent Med & Infect Dis, CH-1015 Lausanne, Switzerland Univ Lausanne Lausanne Switzerland CH-1015 CH-1015 Lausanne, Switzerland Cantonal Hosp Lugano, Div Internal Med, Lugano, Switzerland Cantonal Hosp Lugano Lugano Switzerland ternal Med, Lugano, Switzerland Univ Basel, Outpatient Dept Internal Med, CH-4003 Basel, Switzerland Univ Basel Basel Switzerland CH-4003 nal Med, CH-4003 Basel, Switzerland Univ Geneva, Div Infect Dis, CH-1211 Geneva 4, Switzerland Univ Geneva Geneva Switzerland 4 fect Dis, CH-1211 Geneva 4, Switzerland Cantonal Hosp St Gall, Div Internal Med, St Gallen, Switzerland Cantonal Hosp St Gall St Gallen Switzerland Med, St Gallen, Switzerland Univ Bristol, Dept Social Med, MRC, Hlth Serv Res Collaborat, Bristol BS8 1TH, Avon, England Univ Bristol Bristol Avon England BS8 1TH Bristol BS8 1TH, Avon, England
Titolo Testata:
AIDS
fascicolo: 4, volume: 15, anno: 2001,
pagine: 501 - 507
SICI:
0269-9370(20010309)15:4<501:DOPPIH>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVE ANTIRETROVIRAL THERAPY; HUMAN-IMMUNODEFICIENCY-VIRUS; OPPORTUNISTIC INFECTIONS; COMBINATION THERAPIES; AIDS; CHEMOPROPHYLAXIS; COHORT; SWITZERLAND; PROGRESSION; RESPONSES;
Keywords:
HIV; CD4 cell count; nadir CD4 cell count; plasma HIV RNA; antiretroviral combination therapy; Pneumocystis carinii pneumonia; primary prophylaxis; discontinuation of prophylaxis; immune reconstitution; cohort study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Furrer, H Univ Hosp Bern, Div Infect Dis, CH-3010 Bern, Switzerland Univ Hosp Bern Bern Switzerland CH-3010 3010 Bern, Switzerland
Citazione:
H. Furrer et al., "Discontinuation of primary prophylaxis in HIV-infected patients at high risk of Pneumocystis carinii pneumonia: prospective multicentre study", AIDS, 15(4), 2001, pp. 501-507

Abstract

Objectives: To assess the safety of discontinuation of primary prophylaxisin HIV-infected patients on antiretroviral combination therapy at high risk of developing Pneumocystis carinii pneumonia. Design: Prospective multicentre study. Patients and methods: The incidence of P. carinii pneumonia after discontinuation of primary prophylaxis was studied in 396 HIV-infected patients on antiretroviral combination therapy who experienced an increase in their CD4cell count to at least 200 x 10(6)/l and 14% of total lymphocytes; the study population included 191 patients with a history of CD4 cell counts below100 x 10(6)/l (245 person-years) and 144 patients with plasma HIV RNA above 200 copies/ml (215 person-years). Results: There was one case of Pneumocystis pneumonia, an incidence of 0.18 per 100 person-years [95% confidence interval (CI), 0.005-1.0 per 100 person-years]. No case was diagnosed in groups with low nadir CD4 cell counts (95% CI, 0-1.2 per 100 person-years) or detectable plasma HIV RNA (95% CI, 0-1.4 per 100 person-years). Conclusions: Discontinuation of primary prophylaxis against Pneumocystis pneumonia is safe in patients who have responded with a sustained increase in their CD4 cell count to antiretroviral combination therapy, irrespective of the CD4 cell count nadir and the viral load at the time of stopping prophylaxis. (C) 2001 Lippincott Williams Sc Wilkins.

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Documento generato il 15/07/20 alle ore 07:01:03