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Titolo:
Puerarin blocks transient ourward K+ current and delayed rectifier K+ current in mice hippocampal CA(1) neurons
Autore:
Zhang, GQ; Hao, XM; Zhou, PA; Wu, CH; Dai, DZ;
Indirizzi:
Peking Univ, Natl Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China Peking Univ Beijing Peoples R China 100871 ijing 100871, Peoples R China China Pharmaceut Univ, Res Div Pharmacol, Nanjing 210009, Peoples R China China Pharmaceut Univ Nanjing Peoples R China 210009 09, Peoples R China
Titolo Testata:
ACTA PHARMACOLOGICA SINICA
fascicolo: 3, volume: 22, anno: 2001,
pagine: 253 - 256
SICI:
0253-9756(200103)22:3<253:PBTOKC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL REPERFUSION INJURY;
Keywords:
hippocampus; puerarin; potassium channels; patch-clamp techniques;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Dai, DZ Peking Univ, Natl Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China Peking Univ Beijing Peoples R China 100871 0871, Peoples R China
Citazione:
G.Q. Zhang et al., "Puerarin blocks transient ourward K+ current and delayed rectifier K+ current in mice hippocampal CA(1) neurons", ACT PHAR SI, 22(3), 2001, pp. 253-256

Abstract

AIM: To study the effects of puerarin (Pue) on I-A and I-K in mouse hippocampal neurons. METHODS: The whole cell patch clamp techniques were used. RESULTS: Pue reduced the amplitude of I-A and I-K, in a concentration-dependent, but not rate- or use-dependent manner (IC50 were 461 mu mol/L and 215 mu mol/L, respectively). Pue (0.5 mmol/L) shifted the steady state activation curves of I-A and I-K to positive and negative potentials (V-h about 20.6mV and 28.6 mV) respectively, but inactivation curves of I-A, were not affected by Pue. CONCLUSION: Pue inhibited I-A and I-K in mouse hippocampal CA(1) neurons and its blocking effect on I-K was much stronger than on I-A.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 13:38:52