Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Anxiolytic effect of BPC-157, a gastric pentadecapeptide: shock probe/burying test and light/dark test
Autore:
Sikiric, P; Jelovac, N; Jelovac-Gjeldum, A; Dodig, G; Starfesinic, M; Anic, T; Zoricic, I; Perovic, D; Aralica, G; Buljat, G; Prkacin, I; Lovric-Bencic, M; Separovic, J; Seiwerth, S; Rucman, R; Petek, M; Turkovic, B; Ziger, T;
Indirizzi:
Univ Zagreb, Fac Med, Dept Pharmacol, Zagreb 10000, Croatia Univ Zagreb Zagreb Croatia 10000 , Dept Pharmacol, Zagreb 10000, Croatia
Titolo Testata:
ACTA PHARMACOLOGICA SINICA
fascicolo: 3, volume: 22, anno: 2001,
pagine: 225 - 230
SICI:
0253-9756(200103)22:3<225:AEOBAG>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR ANTAGONISTS; DARK TEST; RESTRAINT STRESS; MICE; ANXIETY; RATS; LESIONS; DIAZEPAM; MODELS; SUPERSENSITIVITY;
Keywords:
BPC-157; diazepam; anxiety; exploratory behavior; motor activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Sikiric, P Univ Zagreb, Fac Med, Dept Pharmacol, Salata 11,POB 916, Zagreb10000, Croatia Univ Zagreb Salata 11,POB 916 Zagreb Croatia 10000 00, Croatia
Citazione:
P. Sikiric et al., "Anxiolytic effect of BPC-157, a gastric pentadecapeptide: shock probe/burying test and light/dark test", ACT PHAR SI, 22(3), 2001, pp. 225-230

Abstract

AIM: To study anxiolytic effect of a gastric pentadecapeptide, BPC-157. METHODS: In shock probe/ burying test, pentadecapeptide BPC-157 (10 mug/kg, 10 ng/kg, ip), diazepam (0.075, 0.0375 mg/kg, ip), and an equivolume of saline (5 mL/kg, ip) were given at 30 min prior test. In light/dark test, the same dosage of diazepam, BPC-157, and saline were given at 45 min prior procedure. RESULTS: Shock probe/burying test: mts treated with either diazepam or pentadecapeptide BPC-157 were much less afraid after the shock: almost not burying and the total time spent in burying was clearly less than in controls. However, while in the diazepam treated rats the number of shocks received increased over control values, in pentadecapeptide BPC-157 treated groups the number of shocks remained not modified compared with the control values. Light/dark test: after exposure to the intense light, diazepam treated mice had longer latencies of crossing to the dark compartment, a greaternumber of crossing and a greater number of exploratory rearing, and spent longer time in the light compartment, as compared to the control mice, while BPC-157 mice had a similar behavior to that of the control mice. In contrast with the effect in light area, in dark zone diazepam produced no changewith respect to controls, while BPC-157 (10 mug/kg) mice had a greater number of crossing and a greater number of exploratory rearing. CONCLUSION: Both diazepam and BPC-157 displayed a bidirectional effect, but the activity of pentadecapeptide BPC-157 was particular, and different from diazepam.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 09:49:29