Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Differential susceptibility of resting CD4(+) T lymphocytes to a T-tropic and a macrophage (M)-tropic human immunodeficiency virus type 1 is associated with their surface expression of CD38 molecules
Autore:
Horikoshi, H; Kinomoto, M; Sasao, F; Mukai, T; Luftig, RB; Ikuta, K;
Indirizzi:
Osaka Univ, Dept Virol, Res Inst Microbial Dis, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 ial Dis, Suita, Osaka 5650871, Japan Louisiana State Univ, Ctr Hlth Sci, Dept Microbiol Immunol & Parasitol, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA
Titolo Testata:
VIRUS RESEARCH
fascicolo: 1, volume: 73, anno: 2001,
pagine: 1 - 16
SICI:
0168-1702(200101)73:1<1:DSORCT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMATOPOIETIC STEM-CELLS; HIV-1 INFECTION; HLA-DR; IN-VIVO; DISEASE PROGRESSION; ANTIGEN EXPRESSION; ACTIVATION; REPLICATION; RECEPTOR; ENTRY;
Keywords:
AIDS; HIV; CD38; CD45; chemokine receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Ikuta, K Osaka Univ, Dept Virol, Res Inst Microbial Dis, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 5650871, Japan
Citazione:
H. Horikoshi et al., "Differential susceptibility of resting CD4(+) T lymphocytes to a T-tropic and a macrophage (M)-tropic human immunodeficiency virus type 1 is associated with their surface expression of CD38 molecules", VIRUS RES, 73(1), 2001, pp. 1-16

Abstract

Recent evidence has accumulated which definitively shows that chemokine receptors CCR5 and CXCR4 play an essential role as coreceptors for human immunodeficiency virus type 1 (HIV-1) infection. Flow cytometric analysis permitted us to detect CD38, a surface marker of early differentiation, as well as activation of T cells, on about half of healthy donor-derived CB4(+) T cells. In this study, we focused on the susceptibility of CD38(+) and CD38(-) subsets of CD4(+) T cells to HIV-I infection with different coreceptor tropisms. About 20% of peripheral blood mononuclear cell-derived resting CD4() T cells were recovered into the CD38(+) subset fraction by panning with a monoclonal antibody to CD38. Most of the cells in this CD38(high) fraction also expressed CD45RA and CD62L at higher intensities compared with thoseof CD38(low) fraction. CCR5(+) T cells predominated in the CD38(-) subset,although cell surface expression of CD4 and CXCR4 was almost similar between both subsets. This difference was consistent with a significantly highersusceptibility of the CD38(-) subset to a macrophage (M)-tropic HIV-1 strain. In contrast, it was shown that a T-tropic strain of HIV-1 could replicate more efficiently in the CD38(+) subset, although viral adsorption rates were similar between both subsets. Thus, the differential susceptibility ofCD4(+) T cells to M- and T-tropic HIV-1 was associated with their surface expression of CD38. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:37:20