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Titolo:
Salmonella: Immune responses and vaccines
Autore:
Mastroeni, P; Chabalgoity, JA; Dunstan, SJ; Maskell, DJ; Dougan, G;
Indirizzi:
Univ Cambridge, Ctr Vet Sci, Cambridge CB3 0ES, England Univ Cambridge Cambridge England CB3 0ES Sci, Cambridge CB3 0ES, England Inst Higiene, Dept Descarrollo Biotecnol, Lab Invest Vacunas, Montevideo 11600, Uruguay Inst Higiene Montevideo Uruguay 11600 Vacunas, Montevideo 11600, Uruguay Univ London Imperial Coll Sci Technol & Med, Dept Biochem, London SW7 2AZ,England Univ London Imperial Coll Sci Technol & Med London England SW7 2AZ gland
Titolo Testata:
VETERINARY JOURNAL
fascicolo: 2, volume: 161, anno: 2001,
pagine: 132 - 164
SICI:
1090-0233(200103)161:2<132:SIRAV>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
AROMATIC-DEPENDENT SALMONELLA; MAJOR HISTOCOMPATIBILITY COMPLEX; LIVE ATTENUATED SALMONELLA; CELL-MEDIATED-IMMUNITY; III SECRETION SYSTEM; TOXIN FRAGMENT-C; DELTA-T-CELLS; EXPERIMENTAL MOUSE SALMONELLOSIS; DELAYED-TYPE HYPERSENSITIVITY; ENTERICA SEROVAR TYPHIMURIUM;
Keywords:
Salmonella; vaccines; immunity; infection; veterinary;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
367
Recensione:
Indirizzi per estratti:
Indirizzo: Mastroeni, P Univ Cambridge, Ctr Vet Sci, Madingley Rd, Cambridge CB3 0ES,England Univ Cambridge Madingley Rd Cambridge England CB3 0ES ngland
Citazione:
P. Mastroeni et al., "Salmonella: Immune responses and vaccines", VET J, 161(2), 2001, pp. 132-164

Abstract

Salmonella infections are a serious medical and veterinary problem worldwide and cause concern in the food industry. Vaccination is an effective toolfor the prevention of Salmonella infections. Host resistance to Salmonellarelies initially on the production of inflammatory cytokines leading to the infiltration of activated inflammatory cells in the tissues. Thereafter, T- and B-cell dependent specific immunity develops allowing the clearance of Salmonella microorganisms from the tissues and the establishment of long-lasting acquired immunity to re-infection. The increased resistance that develops after primary infection/ vaccination requires T-cells, cytokines such as IFN gamma, TNF alpha and IL12 in addition to opsonising antibody. However, for reasons that are not fully understood, seroconversion and/or the presence of detectable T-cell memory do not always correlate with the development of acquired resistance to infection. Whole-cell killed vaccines and subunit vaccines are used in the preventionof Salmonella infection in animals and in humans with variable results. A number of early live Salmonella vaccines derived empirically by chemical oru.v. mutagenesis proved to be immunogenic and protective and are still in use despite the need for repeated parenteral administration. Recent progress in the knowledge of the genetics of Salmonella virulence and modern recombinant DNA technology offers the possibility to introduce multiple, defined, attenuating and irreversible mutations into the bacterial genome. This has recently allowed the develop ment of Salmonella strains devoid of significant side effects, but still capable of inducing solid immunity after single oral administration. Live attenuated Salmonella vaccines have been used for the expression of heterologous antigens/proteins that can be successfully delivered to the immune system. Furthermore, Salmonella can transfer plasmids encoding foreign antigens under the control of eukaryotic promoters (DNA vaccines) to antigen-presenting cells resulting in targeted delivery of DNA vaccines to these cells. Despite the great recent advances in the development of Salmonella vaccines, a large proportion of the work has been conducted in laboratory rodents and more research in other animal species is required. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 07:48:01