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Titolo:
The effect of gestational age and placental location on the prediction of pre-eclampsia by uterine artery Doppler velocimetry in low-risk nulliparouswomen
Autore:
Antsaklis, A; Daskalakis, G; Tzortzis, E; Michalas, S;
Indirizzi:
Alexandra Matern Hosp, Dept Obstet & Gynecol 1, Athens, Greece Alexandra Matern Hosp Athens Greece Obstet & Gynecol 1, Athens, Greece
Titolo Testata:
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
fascicolo: 7, volume: 16, anno: 2000,
pagine: 635 - 639
SICI:
0960-7692(200012)16:7<635:TEOGAA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
UTEROPLACENTAL BLOOD-FLOW; INTRAUTERINE GROWTH-RETARDATION; HYPERTENSIVE DISORDERS; 2ND TRIMESTER; PREECLAMPSIA; ULTRASOUND; PREGNANCY; RESISTANCE;
Keywords:
uterine artery; pre-eclampsia; Doppler ultrasound; notch; placental location;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Daskalakis, G 41 Delfon St, Athens 12243, Greece 41 Delfon St Athens Greece 12243 St, Athens 12243, Greece
Citazione:
A. Antsaklis et al., "The effect of gestational age and placental location on the prediction of pre-eclampsia by uterine artery Doppler velocimetry in low-risk nulliparouswomen", ULTRASOUN O, 16(7), 2000, pp. 635-639

Abstract

Objective To assess how placental position and gestational age ran influence the value of a diastolic notch of the uterine arteries as a screening test for pre-eclampsia. In a low-risk population of healthy nulliparous women. Methods Color Doppler ultrasound was used to examine both uterine arteriesin 654 healthy nulliparas at 4-week intervals between 20 and 32 weeks. Theonly criterion for an abnormal result was the presence of an early diastolic notch. In each subject the placental position was also recorded. The major end points were pre-eclampsia and pre-eclampsia requiring delivery before the 34th week. Results Ninety-eight women (15%) had abnormal flow velocity waveforms at their first visit. Twenty-one out of 654 women developed ere-eclampsia (3.2%). The sensitivity of the test became lower as gestational age advanced andranged from 81% at 20 weeks, to 71.4% at 32 weeks. In contrast, the specificity and positive predictive value increased significantly. Eleven out of 12 women who delivered before 34 weeks had abnormal waveforms at the 24th week. In women with a full lateral placenta, the predictive value of the test was extremely low, especially in cases with unilateral notches. Conclusion Pre-eclampsia can be more accurately predicted if, along with the presence of a notch, both gestational age and placental position ale taken into account. At week 24 the test maintains a high sensitivity (76.1%), but also has an improved specificity (95.1%) and positive predictive value (34%), which allow the clinician to intervene with a potential preventive treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 10:49:15