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Titolo:
Analysis of the development of normal foregut and tracheoesophageal fistula in an adriamycin rat model using three-dimensional image reconstruction
Autore:
Sasaki, T; Kusafuka, T; Okada, A;
Indirizzi:
Osaka Univ, Sch Med, Dept Pediat Surg, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 at Surg, Suita, Osaka 5650871, Japan
Titolo Testata:
SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY
fascicolo: 2, volume: 31, anno: 2001,
pagine: 133 - 139
SICI:
0941-1291(2001)31:2<133:AOTDON>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESOPHAGEAL ATRESIA; SONIC HEDGEHOG; BRANCHING MORPHOGENESIS; HUMAN-EMBRYOS; LUNG; ANOMALIES; EXPRESSION; GROWTH;
Keywords:
tracheoesophageal fistula; three-dimensional image reconstruction; foregut development; adriamycin; rat model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Sasaki, T Osaka Univ, Sch Med, Dept Pediat Surg, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 650871, Japan
Citazione:
T. Sasaki et al., "Analysis of the development of normal foregut and tracheoesophageal fistula in an adriamycin rat model using three-dimensional image reconstruction", SURG TODAY, 31(2), 2001, pp. 133-139

Abstract

To examine the developmental process of the normal trachea and esophagus and their maldevelopment leading to tracheoesophageal fistula (TEF), we performed three-dimensional (3-D) image reconstruction of the developing foregut in normal and adriamycin (ADM)-induced TEF rats. Microscopic images of serial sections of embryos from seven normal and 14 ADM-treated rats killed every half a day after 11-14 days' gestation were traced and reconstructed using a 3-D construction imaging system (TRI, RATOC System Engineering, Tokyo, Japan). In the normal embryos, the lung bud appeared just below the pharyngeal foregut on day 11 and it elongated caudally to shape into the trachea as they grew. A "tracheoesophageal septum" did not emerge. In the TEF embryos, although the lung bud appeared in a similar position on day 11, the trachea and esophagus did not separate and only a common foregut tube elongated caudally, then bilateral bronchial primordia emerged directly from it. Furthermore, abnormal development of the notochord was evident, being retarded in separation from the foregut, finally descending along a more ventralcourse and bending sharply around the level of the bifurcation. Microscopically, less mesenchymal cellularity around the foregut was noted in the TEFembryos. The trachea seemed to be formed only by caudal elongation of the lung bud in the normal embryos. In the ADM-induced TEF embryos, the upper foregut appeared to develop only into the trachea, and this maldevelopment may be implicated in the abnormal interaction between the foregut and the surrounding mesenchyme.

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Documento generato il 28/01/20 alle ore 20:57:42