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Titolo:
Correlations between clinical findings and magnetization transfer imaging metrics of tissue damage in individuals with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
Autore:
Iannucci, G; Dichgans, M; Rovaris, M; Bruning, R; Gasser, T; Giacomotti, L; Yousry, TA; Filippi, M;
Indirizzi:
Hosp San Raffaele, Inst Sci, Dept Neurosci, Neuroimaging Res Unit, I-20132Milan, Italy Hosp San Raffaele Milan Italy I-20132 ging Res Unit, I-20132Milan, Italy Univ Munich, Klinikum Grosshadern, Dept Neurol, Munich, Germany Univ Munich Munich Germany um Grosshadern, Dept Neurol, Munich, Germany Univ Munich, Klinikum Grosshadern, Dept Radiol, D-8000 Munich, Germany Univ Munich Munich Germany D-8000 n, Dept Radiol, D-8000 Munich, Germany Univ Munich, Klinikum Grosshadern, Dept Neuroradiol, D-8000 Munich, Germany Univ Munich Munich Germany D-8000 pt Neuroradiol, D-8000 Munich, Germany
Titolo Testata:
STROKE
fascicolo: 3, volume: 32, anno: 2001,
pagine: 643 - 648
SICI:
0039-2499(200103)32:3<643:CBCFAM>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE-SCLEROSIS; WHITE-MATTER; MICROSCOPIC DISEASE; T2-WEIGHTED IMAGES; NOTCH3 MUTATIONS; TRANSFER RATIO; AXONAL LOSS; CADASIL; BRAIN; LESIONS;
Keywords:
CADASIL; magnetic resonance imaging; magnetization transfer imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Filippi, M Hosp San Raffaele, Inst Sci, Dept Neurosci, Neuroimaging Res Unit, Via Olgettina 60, I-20132 Milan, Italy Hosp San Raffaele Via Olgettina 60 Milan Italy I-20132 , Italy
Citazione:
G. Iannucci et al., "Correlations between clinical findings and magnetization transfer imaging metrics of tissue damage in individuals with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy", STROKE, 32(3), 2001, pp. 643-648

Abstract

Background and Purpose-We obtained magnetization transfer imaging (MTI) scans from individuals with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) (1) to investigate the presence, extent, and nature of pathology in white and gray matter outside proton density (PD)-visible lesions; (2) to quantify the degree of tissue damage occurring in lesions seen on PD-weighted scans; and (3) to correlate MTI-derived measures of disease burden with age, physical disability, and cognitive performance. Methods-Dual-echo, T1-weighted, and MTI scans of the brain were obtained from 33 individuals with CADASIL and 12 control subjects. Magnetization transfer ratio (MTR) values from PD-visible lesions, normal-appearing white matter (NAWM), and normal-appearing gray matter (NAGM) were measured. Histograms of MTR from the whole brain and normal-appearing brain tissue were also produced. Results-All MTR values from NAWM and NAGM regions studied were significantly lower for individuals with CADASIL than for control subjects, with the exception of those obtained from the NAWM of the infratentorial structures and the NAGM of the occipital cortex. The average MTR from PD lesions in individuals with CADASIL was significantly lower than that from all the NAWM regions. Average MTR and peak location from whole-brain and normal-appearingbrain tissue histograms were significantly lower for individuals with CADASIL than for control subjects. MTR values from NAWM were strongly correlated with the extent of macroscopic lesions and their average MTR, Apart from NAGM, average MTR from all other tissues studied significantly decreased with increasing age, physical disability, and cognitive impairment. Conclusions-PD lesions of individuals with CADASIL have variable degrees of tissue damage. Brain tissue outside PD abnormalities is also damaged. This study suggests that the extent and the severity of the brain tissue damage are critical factors in determining clinical status in CADASIL.

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Documento generato il 06/07/20 alle ore 05:55:59