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Titolo:
MR imaging of the wrist in rheumatoid arthritis using gadobenate dimeglumine
Autore:
Bonel, HM; Schneider, P; Seemann, MD; Huegli, R; Srivastav, S; Lodemann, KP; Reiser, M;
Indirizzi:
Univ Munich, Inst Clin Radiol, D-81377 Munich, Germany Univ Munich Munich Germany D-81377 Clin Radiol, D-81377 Munich, Germany Univ Calif San Francisco, Osteoporosis & Arthrit Res Grp, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Tubingen, Dept Radiol Diagnoses, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 gnoses, D-72076 Tubingen, Germany Tulane Univ, Dept Biostat, New Orleans, LA 70112 USA Tulane Univ New Orleans LA USA 70112 t Biostat, New Orleans, LA 70112 USA Bracco Byk Gulden GMBH, D-78467 Constance, Germany Bracco Byk Gulden GMBHConstance Germany D-78467 8467 Constance, Germany
Titolo Testata:
SKELETAL RADIOLOGY
fascicolo: 1, volume: 30, anno: 2001,
pagine: 15 - 24
SICI:
0364-2348(200101)30:1<15:MIOTWI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTRAST AGENTS; GD-DOTA; KNEE; DTPA; ENHANCEMENT; SYSTEM; BOPTA;
Keywords:
gadobenate dimeglumine; Gd-BOPTA; magnetic resonance imaging; rheumatoid arthritis; diagnostic imaging; low-field MRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Bonel, HM Univ Munich, Inst Clin Radiol, Marchioninistr 15, D-81377 Munich, Germany Univ Munich Marchioninistr 15 Munich Germany D-81377 h, Germany
Citazione:
H.M. Bonel et al., "MR imaging of the wrist in rheumatoid arthritis using gadobenate dimeglumine", SKELETAL RA, 30(1), 2001, pp. 15-24

Abstract

Objective. To determine the dosage of gadobenate dimeglumine (Gd-BOPTA) necessary for MRI of rheumatoid arthritis of the wrist. Design and patients. Seven wrists inflamed with rheumatoid arthritis were imaged using a dedicated 0.2-T MR unit. Four cumulative dosages of 0.0125, 0.025, 0.05 and 0.1 mmol/kg body weight (BW) Gd-BOPTA were tested. Three-dimensional T1-weighted gradient-recalled echo sequences (GRE; TR: 100 ms, TE: 18 ms, flip angle 90 degrees, 4:55 min) were acquired prior to an intravenous injection and after each additional dosage of Gd-BOPTA. Relative enhancement, signal-difference-to-noise ratios (SDNRs) and the size of the inflamed tissue were quantified. Three radiologists independently evaluated the image quality, the size and the contrast of the enhancing tissue. Results. The readers agreed on a dose of 0.05 mmol/kg BW as satisfactory for the evaluation of the size of the inflammatory tissue and for determination of bone involvement (kappa =0.9, P<0.001). Highly inflammatory pannus was depicted with adequate image contrast using 0.025 mmol/kg BW Gd-BOPTA. According to the SDNR and relative enhancement findings, a dose of 0.05 mmol/kg BW suffices for both off-center and centered regions of tissue inflammation (t-test, P<0.05). Conclusion. Gadolinium-BOPTA is an alternative contrast agent for MRI of rheumatoid disease. This study shows that a dose of 0.05 mmol/kg BW suffices at low field strength.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:48:24