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Titolo:
AMP-ACTIVATED PROTEIN-KINASE ISOENZYME FAMILY - SUBUNIT STRUCTURE ANDCHROMOSOMAL LOCATION
Autore:
STAPLETON D; WOOLLATT E; MITCHELHILL KI; NICHOLL JK; FERNANDEZ CS; MICHELL BJ; WITTERS LA; POWER DA; SUTHERLAND GR; KEMP BE;
Indirizzi:
ST VINCENTS HOSP,ST VINCENTS INST MED RES,41 VICTORIA PARADE FITZROY VIC 3065 AUSTRALIA ST VINCENTS HOSP,ST VINCENTS INST MED RES FITZROY VIC 3065 AUSTRALIA ST VINCENTS HOSP,DEPT CLIN IMMUNOL FITZROY VIC 3065 AUSTRALIA DARTMOUTH COLL SCH MED,DEPT MED,DIV ENDOCRINOL & METAB HANOVER NH 03755 DARTMOUTH COLL SCH MED,DEPT BIOCHEM HANOVER NH 03755 MOL GENET WOMENS & CHILDRENS HOSP,DEPT CYTOGENET,CTR GENET MED ADELAIDE SA 5006 AUSTRALIA
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 409, anno: 1997,
pagine: 452 - 456
SICI:
0014-5793(1997)409:3<452:APIF-S>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
YEAST; METABOLISM;
Keywords:
AMP-ACTIVATED PROTEIN KINASE; ISOFORM; GENE; CHROMOSOME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
D. Stapleton et al., "AMP-ACTIVATED PROTEIN-KINASE ISOENZYME FAMILY - SUBUNIT STRUCTURE ANDCHROMOSOMAL LOCATION", FEBS letters, 409(3), 1997, pp. 452-456

Abstract

The AMP-activated protein kinase (AMPK) consists of catalytic alpha and non-catalytic, beta and gamma(38 kDa) subunits and is responsible for acting as a metabolic sensor for AMP levels. There are multiple genes for each subunit and we find that rat liver AMPK-alpha 2 isoform catalytic subunit is associated with beta 1 and gamma 1 and not beta 2 or gamma 2 subunit isoforms. The beta 1 and gamma 1 isoforms are also subunits of the alpha 1 isoform. The sequence of cloned human AMPK-beta1 is 95% identical in amino acid sequence with rat beta 1. Human chromosomal localizations were determined for AMPK-alpha 1 (5p11-p14), AMPK-beta 1 (12q24.1-24.3) and AMPK-gamma 1 (12q12-q14), respectively. (C) 1997 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 18:48:59