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Titolo:
Parathormon, calcium, phosphorus, and left ventricular structure and function in normotensive hemodialysis patients
Autore:
Strozecki, P; Adamowicz, A; Nartowicz, E; Odrowaz-Sypniewska, G; Wlodarczyk, Z; Manitius, J;
Indirizzi:
Ludwik Rydygier Med Univ, Dept Nephrol, Bydgoszcz, Poland Ludwik Rydygier Med Univ Bydgoszcz Poland pt Nephrol, Bydgoszcz, Poland
Titolo Testata:
RENAL FAILURE
fascicolo: 1, volume: 23, anno: 2001,
pagine: 115 - 126
SICI:
0886-022X(2001)23:1<115:PCPALV>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
STAGE RENAL-DISEASE; PARATHYROID-HORMONE; DIALYSIS PATIENTS; ECHOCARDIOGRAPHIC FINDINGS; INTRAVENOUS CALCITRIOL; CARDIOVASCULAR-DISEASE; DIASTOLIC FUNCTION; CARDIAC-FUNCTION; LONG-TERM; HYPERTROPHY;
Keywords:
parathormon; calcium; phosphorus; blood pressure; echocardiography; left ventricular hypertrophy; left ventricular diastolic function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Strozecki, P Ludwik Rydygier Med Univ, Dept Nephrol, Bydgoszcz, Poland Ludwik Rydygier Med Univ Bydgoszcz Poland ydgoszcz, Poland
Citazione:
P. Strozecki et al., "Parathormon, calcium, phosphorus, and left ventricular structure and function in normotensive hemodialysis patients", RENAL FAIL, 23(1), 2001, pp. 115-126

Abstract

Clinical and experimental data suggest that Parathormon (PTH), calcium, and phosphorus participate in left ventricular hypertrophy (LVH) and affect myocardial contractility in end-stage renal disease. Cellular calcium overload and interstitial fibrosis induced by PTH may lead to impairment of left ventricular diastolic function. Hyperphosphatemia is an independent risk ofcardiovascular mortality in dialysis patients. The aim of the study was toestimate the influence of PTH acid calcium-phosphorus metabolism on left ventricular structure and function in hemodialysis patients, without hypertension and antihypertensive drug therapy (SBP = 126.2 +/- 11.1 DBP = 75.8 +/- 6.5 mmHg). Echocardiographic findings in a group of 22 normotensive HD patients had been compared to 43 hypertensive HD patients. Relationships between PTH, calcium-phosphorus metabolism and echocardiography in normotensivegroup were then evaluated. Left ventricular mass index (LVMI) was lower innormotensive patients. 128.3 +/- 46.2 versus 165.8 +/- 46.7 (p < 0.01). The prevalence of LVH was 55% in normotensive HD patients compared to 86% in hypertensive group (p < 0.01). In normotensive group we found correlation between PTH and LVMI (r = 0.44; p < 0.05). There were also significant relation ships between calcium and posterior wall thickness (r = -0.44; p < 0.05), phosphorus and LVMI (r = 0.47; p < 0.05). A significant correlation was observed between both phosphorus, calcium x phosphorus product and E/A ratio: r = -0.47 and r = -0.43, respectively (p < 0.05 both). Disturbances of calcium-phosphorus metabolism and secondary hyperparathyroidism contributes to left ventricular hypertrophy, and impaired left ventricular diastolic function in normotensive hemodialysis patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:01:25