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Titolo:
Modulation of nitrergic relaxant responses by peptides in the mouse gastric fundus
Autore:
Baccari, MC; Calamai, F;
Indirizzi:
Univ Florence, Dept Physiol, I-50134 Florence, Italy Univ Florence Florence Italy I-50134 pt Physiol, I-50134 Florence, Italy
Titolo Testata:
REGULATORY PEPTIDES
fascicolo: 1-2, volume: 98, anno: 2001,
pagine: 27 - 32
SICI:
0167-0115(20010402)98:1-2<27:MONRRB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLASE-ACTIVATING PEPTIDE; VASOACTIVE-INTESTINAL-PEPTIDE; NITRIC-OXIDE; INHIBITORY TRANSMISSION; POLYPEPTIDE PACAP; VIP; RECEPTORS; RAT; MUSCLE; COLON;
Keywords:
neuromodulation; VIP; nitric oxide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Baccari, MC Univ Florence, Dept Physiol, Viale GB Morgagni 63, I-50134 Florence, Italy Univ Florence Viale GB Morgagni 63 Florence Italy I-50134 aly
Citazione:
M.C. Baccari e F. Calamai, "Modulation of nitrergic relaxant responses by peptides in the mouse gastric fundus", REGUL PEPT, 98(1-2), 2001, pp. 27-32

Abstract

The effects of pituitary adenylate cyclase-activating peptide (PACAP-38) and vasoactive intestinal polypeptide (VIP) were investigated in the gastricfundus strips of the mouse. In carbachol (CCh) precontracted strips, in the presence of guanethidine, electrical field stimulation (EFS) elicited a fast inhibitory response that may be followed, at the highest stimulation frequencies employed, by a sustained relaxation. The fast response was abolished by the nitric oxide (NO) synthesis inhibitor L-N-G-nitro arginine (L-NNA) or by the guanylate cyclase inhibitor (ODQ), the sustained one by alpha -chymotrypsin. alpha -Chymotrypsin also increased the amplitude of the EFS-induced fast relaxation. PACAP-38 and VIP caused tetrodotoxin-insensitive sustained relaxant responses that were both abolished by alpha -chymotrypsin. Apamin did not influence relaxant responses to EFS nor relaxation to bothpeptides. PACAP 6-38 abolished EFS-induced sustained relaxations, increased the amplitude of the fast ones and antagonized the smooth muscle relaxation to both PACAP-38 and VIP. VIP 10-28 and [D-p-Cl-Phe(6),Leu(17)]-VIP did not influence the amplitude of both the fast or the sustained response to EFS nor influenced the relaxation to VIP and PACAP-38. The results indicate that in strips from mouse gastric fundus peptides, other than being responsible for EFS-induced sustained relaxation, also exerts a modulatory action on the release of the neurotransmitter responsible for the fast relaxant response, that appears to be NO. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:11:22