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Titolo:
Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
Autore:
Vila, M; Jackson-Lewis, V; Vukosavic, S; Djaldetti, R; Liberatore, G; Offen, D; Korsmeyer, SJ; Przedborski, S;
Indirizzi:
Columbia Univ, Dept Neurol, New York, NY 10032 USA Columbia Univ New YorkNY USA 10032 , Dept Neurol, New York, NY 10032 USA Columbia Univ, Dept Pathol, New York, NY 10032 USA Columbia Univ New YorkNY USA 10032 , Dept Pathol, New York, NY 10032 USA Felsenstein Res Ctr, IL-69978 Petah Tiqwa, Israel Felsenstein Res Ctr Petah Tiqwa Israel IL-69978 9978 Petah Tiqwa, Israel Harvard Univ, Sch Med, Dana Farber Canc Inst, Howard Hughes Med Inst,Dept Pathol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 d Inst,Dept Pathol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dana Farber Canc Inst, Howard Hughes Med Inst,Dept Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Med Inst,Dept Med, Boston, MA 02115 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 5, volume: 98, anno: 2001,
pagine: 2837 - 2842
SICI:
0027-8424(20010227)98:5<2837:BAPDNI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; TROPHIC FACTOR DEPRIVATION; SUBSTANTIA-NIGRA; DEFICIENT MICE; CYTOCHROME-C; TYROSINE-HYDROXYLASE; NEURONAL DEATH; NITRIC-OXIDE; TOXIN MPTP; IN-VIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Przedborski, S Columbia Univ, Dept Neurol, BB-307,650 W 168th St, New York, NY 10032 USA Columbia Univ BB-307,650 W 168th St New York NY USA 10032 A
Citazione:
M. Vila et al., "Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease", P NAS US, 98(5), 2001, pp. 2837-2842

Abstract

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) damages dopaminergic neurons in the substantia nigra pars compacta (SNpc) as seen in Parkinson's disease. Here, we show that the proapoptotic protein Bax is highly expressed in the SNpc and that its ablation attenuates SNpc developmental neuronal apoptosis. In adult mice, there is an up-regulation of Bax in the SNpc after MPTP administration and a decrease in Bcl-2. These changes parallel MPTP-induced dopaminergic neurodegeneration. We also show that mutant mice lacking Bax are significantly more resistant to MPTP than their wild-type littermates. This study demonstrates that Bax plays a critical role in the MPTP neurotoxic process and suggests that targeting Bax may provide protective benefit in the treatment of Parkinson's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 20:01:32