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Titolo:
In vivo evidence for a cochlear amplifier in the hair-cell bundle of lizards
Autore:
Manley, GA; Kirk, DL; Koppl, C; Yates, GK;
Indirizzi:
Tech Univ Munich, Inst Zool, D-85747 Garching, Germany Tech Univ Munich Garching Germany D-85747 ool, D-85747 Garching, Germany Univ Western Australia, Dept Physiol, Nedlands, WA 6907, Australia Univ Western Australia Nedlands WA Australia 6907 nds, WA 6907, Australia
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 5, volume: 98, anno: 2001,
pagine: 2826 - 2831
SICI:
0027-8424(20010227)98:5<2826:IVEFAC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVOKED OTOACOUSTIC EMISSIONS; MECHANOELECTRICAL-TRANSDUCTION; MECHANICAL AMPLIFICATION; TONOTOPIC ORGANIZATION; TILIQUA-RUGOSA; ADAPTATION; CHANNELS; MOTION; INNERVATION; MOVEMENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Manley, GA Tech Univ Munich, Inst Zool, D-85747 Garching, Germany Tech Univ Munich Garching Germany D-85747 7 Garching, Germany
Citazione:
G.A. Manley et al., "In vivo evidence for a cochlear amplifier in the hair-cell bundle of lizards", P NAS US, 98(5), 2001, pp. 2826-2831

Abstract

Vertebrate sensory hair cells achieve high sensitivity and frequency selectivity by adding self-generated mechanical energy to low-level signals. This allows them to detect signals that are smaller than thermal molecular motion and to achieve significant resonance amplitudes and frequency selectivity despite the viscosity of the surrounding fluid. In nonmammals, a great deal of in vitro evidence indicates that the active process responsible for this amplification is intimately associated with the hair cells' transduction channels in the stereovillar bundle, Here, we provide in vivo evidence of hair-cell bundle involvement in active processes. Electrical stimulation of the inner ear of a lizard at frequencies typical for this hearing organ induced low-level otoacoustic emissions that could be modulated by low-frequency sound. The unique modulation pattern permitted the tracing of the active process involved to the stereovillar bundles of the sensory hair cells. This supports the notion that, in nonmammals, the cochlear amplifier in the hair cells is driven by a bundle motor system.

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Documento generato il 28/11/20 alle ore 04:31:48